Arsenic acid (H3AsO4)

141.94

141.94

231-901-9

N7CIZ75ZPN

1625

1553|1554

DTXSID1034341

WHITE TRANSLUCENT CRYSTALS /HEMIHYDRATE/|75% COMMERCIAL GRADE IS A VERY PALE YELLOW, SYRUPY LIQ /COMMERCIAL GRADE/|Exist only in solution|White, crystalline solid

77.76000

-2.17060

Arsenic acid, liquid appears as a clear colorless aqueous solution. Noncombustible. Corrosive to metals. Toxic by ingestion. Confirmed human carcinogen. Detrimental to the environment. Immediate steps should be taken to limit release.

2.2 g/cm³ (approx)

35 °C

160ºC

H2O: 0.1 g/100 mL (20 ºC)

Arsenic acid should be kept stored in an area without drain or sewer access. It should be separated from strong oxidants, strong bases, metals, strong reducing agents, food, and feedstuffs. Occupational workers should keep arsenic acid in a cool, well-ventilated area, away from heat. Workers should avoid storing or transporting arsenic acid with aluminium, copper, iron, or zinc.

Vapor pressure, kPa at 15 °C: 1.3

2.2

Oral-rat LD50: 48 mg/kg; oral-rabbit LDL 0: 5 mg/kg

It produces highly toxic arsenic pentoxide in case of acid; it decomposes toxic arsenic fumes when heated

WEAK ACIDIC PROPERTIES.

PK2= 7.089 +/- 0.01 @ 25 °C

Exists only as the hemihydrate|Releases water when heated above 160 °C forming arsenic pentoxide

Water soluble.|Hygroscopic. Water soluble.

Oxidizing Agents, Weak

ARSENIC ACID SOLUTION may evolve very toxic gaseous arsine (AsH3) from contact with active metals, such as zinc and aluminum [Inorganic Chemicals Handbook, I, p. 175]. When heated to decomposition, it produces toxic fumes of metallic arsenic [Sax, 9th ed., p. 271]. The solution is weakly acidic and a weak oxidizing agent. Reacts with alkalis to generate some heat and precipitate arsenates.|ARSENIC ACID may evolve very toxic gaseous arsine (AsH3) from contact with active metals, such as zinc and aluminum [Inorganic Chemicals Handbook, I, p. 175]. When heated to decomposition, it produces toxic fumes of metallic arsenic [Sax, 9th ed., p. 271]. The solution is weakly acidic and a weak oxidizing agent. Reacts with alkalis to generate some heat and precipitate arsenates.

IT WILL SLOWLY ATTACK MILD STEEL & REACTS WITH GALVANIZED METALS AND BRASS

II

6.1(a)

1554

45-23/25-50/53

53-45-60-61

CG0700000

T, N

Treasury is ventilated, low temperature and dry; stored and transported separately from acids and food

Incompatible with metals.

P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Heavy metals will react with arsenic acid to yield insoluble precipitates. Metals which precipitate arsenic acid include magnesium, lead, calcium, and iron (III). Arsenate precipitation with ferric hydroxide has been suggested to reduce its phytotoxicity. Its precipitation will also reduce its potential for leaching. Arsenate could be suitably precipitated with a slight excess of lime, ferric hydroxide, or magnesium. The best procedure is to stir ferric chloride, or a hydroxide of ferric, calcium, or magnesium into the waste arsenic acid and allow the mixture to stand 24 hr. Then, the supernatant water should be siphoned or decanted. An alternate procedure would be to precipitate arsenic with sulfide. Since the method requires more sophisticated handling, the precipitation with heavy metals is preferred. The sulfide precipitation requires decreasing the soln acidity to < pH 1 with 6 N-HCL /6 N-hydrochloric acid/, then saturating the soln with sodium sulfide or hydrogen sulfide. The precipitate and supernatant should be handled just as described for the ferric or other metal arsenate precipitates. Empty containers should be triple rinsed. "Triple rinse" means the flushing of containers three times, each time using a volume of the normal diluent equal to approx ten percent of the container's capacity, and adding the rinse liquid to the spray mixture or disposing of it by a method prescribed for disposing of the pesticide. Although the precipitation of arsenic acid could reduce its mobility in the environment and its toxicity, insufficient environmental testing is available to verify this conclusion. The precipitates should be considered hazardous. Recommendable methods: Precipitation, solidification, landfill. Not recommendable methods: Thermal destruction, discharge to sewer.|Arsenic acid is a poor candidate for incineration.|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/

Arsenic acid is a strong oxidant and will oxidize I(-1) ion to I(-3).|... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS ARSENIC, IRON, ALUMINUM, ZINC, ... HIGHLY TOXIC FUMES OF ARSENIC /INCLUDING ARSINE ARE RELEASED/. /ARSENIC CMPD/|Strong oxidizers, bromide azide [Note: Hydrogen gas can react with inorganic arsenic to form the highly toxic gas arsine.] /Arsenic (inorganic compounds, as As)/

USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Chromated Arsenicals EPA 739-R-08-006 (September 2008). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[http://www.epa.gov/pesticides/reregistration/status.htm]|NIOSH; Criteria Document: Inorganic Arsenic (1975) DHEW Pub. NIOSH 75-149|Los Alamos National Laboratory; A Comparison of Trace Level Concentrations for Silver, Arsenic, Barium, Cadmium, and Lead in Drinking Waters Obtained by Inductively Coupled Plasma-Mass Spectrometry and Electrothermal-Vaporization Atomic Absorption Spectroscopy (1987) LA-11095 MS|DHHS/ATSDR; Toxicological Profile for Arsenic (7440-38-2) (PB/2008/100002) (August 2007). The ATSDR toxicological profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is presented in less detail.|For more Special Reports (Complete) data for ARSENIC ACID (9 total), please visit the HSDB record page.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P281, P301+P310, P304+P340, P308+P313, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P311, P312, P314, P321, P322, P330, P363, P403+P233, P405, and P501|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P310, P305+P351+P338, P307+P311, P308+P313, P314, P321, P330, P337+P313, P405, and P501|P201, P202, P260, P264, P270, P281, P301+P310, P307+P311, P308+P313, P314, P321, P330, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)|Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate or lime solution. (USCG, 1999)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)|Calamine lotion and zinc oxide powder on hands and other skin areas; rubber gloves; U. S. Bureau of Mines approved dust respirator. (USCG, 1999)|CALAMINE LOTION & ZINC OXIDE POWDER ON HANDS & OTHER SKIN AREAS; RUBBER GLOVES; USA BUREAU MINES APPROVED DUST RESPIRATOR. /HEMIHYDRATE/|AVOID CONTACT WITH SKIN, EYES, OR CLOTHING. WEAR RESPIRATOR. WASH THOROUGHLY AFTER USING & BEFORE EATING OR SMOKING. KEEP CHILDREN, PETS, LIVESTOCK, & POULTRY AWAY FROM TREATED AREAS. AVOID CONTAMINATION OF FOOD & WATER TO BE CONSUMED. ... /HEMIHYDRATE/|Workers should be supplied with suitable protective clothing, protective boots and when there is a risk that the exposure limit for airborne arsenic will be exceeded, respiratory protective equipment. /Arsenic cmpd/|Where there is occupational exposure to inorganic arsenic compounds, protective clothing shall be provided by the employers. This may include underwear, gloves, coveralls, and a hood over the head and neck. /Inorganic arsenic/|For more Personal Protective Equipment (PPE) (Complete) data for ARSENIC ACID (8 total), please visit the HSDB record page.

Personnel protection: ... Wear positive pressure self contained breathing apparatus when fighting fires involving arsenic acid. /Arsenic acid solution; arsenic acid, solid/|IF material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Arsenic acid, solid/|If material is on fire: Extinguish fire using agent suitable for surrounding fire, since arsenic acid itself does not burn or burns with difficulty. Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenic acid solution/|If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/|If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.|Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

CAUTION: DO NOT GRAZE OR FEED TREATED PLANTS OR GIN WASTE.|If material not involved in fire: Keep material out of water sources and sewers. Neutralize spilled material with crushed limestone, soda ash, or lime. /Arsenic acid, solid/|If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Neutralize spilled material with crushed limestone, soda ash, or lime. /Arsenic acid solution/|Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Arsenic acid solution; arsenic acid, solid/|For more Preventive Measures (Complete) data for ARSENIC ACID (23 total), please visit the HSDB record page.

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Arsenic acid, liquid; Arsenic acid, solid/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Arsenic acid, liquid; Arsenic acid, solid/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Arsenic acid, liquid; Arsenic acid, solid/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Arsenic acid, liquid; Arsenic acid, solid/|For more DOT Emergency Guidelines (Complete) data for ARSENIC ACID (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

ARSENICAL DUSTS ... ARE IRRITATING TO UPPER RESP TRACT & EYES. CONJUNCTIVITIS PRODUCED BY ... THESE SUBSTANCES ARE CHARACTERIZED BY ITCHING, BURNING, & WATERING OF EYES. ... /INORGANIC ARSENIC DUSTS/

8 hr Time-Weighted avg: 10 ug/cu m./Arsenic, inorganic cmpd (as As)/|Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

5 mg/cu m (as As); NIOSH considers arsenic (inorganic cmpd, as As) to be a potential occupational carcinogen. /Arsenic (inorganic cmpd, as As)/|Recommended Exposure Limit: 15 Ceiling Limit: (0.002 mg/cu m). /Arsenic (inorganic cmpd, as As)/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Arsenic (inorganic compounds, as As)/

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable plastic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Store in an area without drain or sewer access. Separated from strong oxidants, strong bases, metals, strong reducing agents and food and feedstuffs. Do NOT store or transport in containers made from aluminium, copper, iron or zinc.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C on spraying.

The substance is corrosive to the eyes, skin and respiratory tract. The substance may cause effects on the blood, cardiovascular system, gastrointestinal tract, liver and nervous system. The effects may be delayed.

The substance may have effects on the peripheral nervous system, skin and cardiovascular system. This may result in polyneuropathy and skin lesions. This substance is carcinogenic to humans.

AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!

Use closed system or ventilation.

Protective gloves. Protective clothing.

Wear face shield.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Arsenic acid is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/|For more Atmospheric Standards (Complete) data for ARSENIC ACID (6 total), please visit the HSDB record page.

P010; An acute hazardous waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate.|D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

P010; As stipulated in 40 CFR 261.33, when arsenic acid, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

most toxic

LD50 Rat oral 48 mg/kg|LD50 Rat oral 48-100 mg/kg (USA tolerance of 4 ppm arsenic oxide equivalent on raw cottonseed).|LD50 Rabbit iv 8 mg/kg.

ENVIRONMENTAL PERSISTENCE: NONVOLATILE UNDER ALL CLIMATIC CONDITIONS. /HEMIHYDRATE/

ABOUT 2/3 OF ARSENIC IN RAIN & LAKEWATER WAS ARSENATE.

An agent that causes the production of physical defects in the developing embryo. (See all compounds classified as Teratogens.)|Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)

SYSTEMIC TOXIC EFFECTS HAVE RESULTED FROM OCCUPATIONAL ACCIDENTS WHEN ARSENIC ACID ... SPLASHED ON WORKERS, INDICATING THAT THE SKIN IS POSSIBLE ROUTE OF ABSORPTION FOR ARSENIC.|MALE & FEMALE HAMSTERS WERE GIVEN EITHER A SINGLE ORAL OR IV DOSE OF (74)AS (33 MICROCURIES/HAMSTER; 0.01 UG ARSENIC/HAMSTER) AS ARSENIC ACID. FOR THE IV DOSED HAMSTERS, HALF-PERIOD OF ELIMINATION FOR THE 1ST COMPONENT (65% OF THE DOSE) WAS 0.40 DAYS; 2ND COMPONENT (35% OF THE DOSE) HAD HALF-PERIOD OF 4.5 DAYS. FOR THE ORALLY DOSED HAMSTERS, THE HALF-PERIOD OF ELIMINATION FOR 1ST COMPONENT (98% OF THE DOSE) WAS 0.29 DAYS; 2ND COMPONENT (2% OF THE DOSE) HAD A HALF-PERIOD OF 3.8 DAYS. DIFFERENCES IN THE PERCENT OF DOSE EXCRETED BETWEEN ORAL & IV DOSED HAMSTERS MAY BE DUE TO THE INCREASED FECAL EXCRETION OF ARSENIC (70%) IN THE ORALLY DOSED ANIMALS AS COMPARED TO THE IV DOSED HAMSTERS (6%).|Autoradiography of mice given carrier-free (74)As arsenic acid (iv) revealed a high affinity of As in the intestinal mucosa as well as in the kidneys.|Percutaneous absorption of (73)As as arsenic acid (H3AsO4) alone and mixed with soil has been measured in skin from cadavers ... . Labeled arsenic was applied to skin in diffusion cells and transit through the skin into receptor fluid measured. After 24 hr, 0.93% of the dose passed through the skin and 0.98% remained in the skin after washing. Absorption was lower with (73)As mixed with soil: 0.43% passed through the skin over 24 hr and 0.33% remained in the skin after washing.|Dermal absorption of arsenic has been measured in Rhesus monkeys ... . After 24 hr, 6.4% of (73)As as arsenic acid was absorbed systemically, as was 4.5% of (73)As mixed with soil.

ANALYSIS OF SAMPLES OF 24 HR URINE FROM MALE & FEMALE HAMSTERS GIVEN EITHER A SINGLE ORAL OR IV DOSE (33 MICROCURIES/HAMSTER; 0.01 UG/HAMSTER) AS ARSENIC ACID, REVEALED THAT ARSENIC WAS PRESENT AS DIMETHYLARSINIC ACID & AS INORGANIC ARSENIC.|The iv administration of carrier free (74)As arsenic acid to an adult male beagle (14.8 MBq, 0.4 m C1), resulted in (74)As being present in plasma or urine predominantly as inorganic arsenic or dimethylarsenic acid.|Plasma, red blood cells, or urine from a beagle were incubated in vitro with (74)As arsenic acid. No methylated arsenic was found in the plasma or urine samples but a small amt (0.2 %) of dimethylarsenic acid was found in the erythrocyte samples.|Rat liver cytosol inactivates inorganic arsenic through methylation; S-adenosylmethionine is the methyl group donor and reduced glutathione is required for full activity. ... Pathway involves the formation of a monomethylated metabolite which is either rapidly further methylated into a dimethylated derivative or is spontaneously oxidized into monomethylarsonic acid. The dimethylated metabolite gives rise to dimethylarsinic acid. The first methylation reaction is rate limiting, can be stimulated by glutathione and is catalyzed by an enzyme different from that which transfers the second methyl group. The latter is sensitive to inhibition by inorganic arsenic. ... A large excess of thiol groups may prevent the methylation reactions probably by decreasing the amount of free trivalent arsenic.

The disappearance of (74)As from the blood of dogs administered iv carrier free (74)As arsenic acid exhibited a 3-phase pharmacokinetic model similar to that of man. Most of the (74)As quickly left the blood (half-life of the first 2 phases of 1 and 5 hr, respectively), while the remaining amt was cleared with a half-life of 35 hr. The small amt of As still present in blood 3 hr after the injection was equally distributed between plasma and erythrocytes.|Whole body retention and elimination in dogs following iv or oral administration of (74)As arsenic acid (0.02 ug As/kg body weight) revealed that 85% of the dose was cleared very rapidly with a half-life of about 6 hr. The second phase of elimination, representing 14% of the dose, had a half-life of 2.4 days. No significant differences were found between iv and oral administration.|... (74)As ... used for the investigation of the uptake and release of different ... arsenic species in Poecilia reticulata. Trimethylarsine /could/ be rapidly taken up directly only from water. ... About 95% of arsenic acid, methylarsenic acid, dimethylarsenic acid or As(III) diethyldithiocarbamate ... released in a few days. The remaining As is released with a biological half life of 35 days.|MALE & FEMALE HAMSTERS WERE GIVEN EITHER A SINGLE ORAL OR IV DOSE OF (74)AS (33 MICROCURIES/HAMSTER; 0.01 UG ARSENIC/HAMSTER) AS ARSENIC ACID. FOR THE IV DOSED HAMSTERS, HALF-PERIOD OF ELIMINATION FOR THE 1ST COMPONENT (65% OF THE DOSE) WAS 0.40 DAYS; 2ND COMPONENT (35% OF THE DOSE) HAD HALF-PERIOD OF 4.5 DAYS. FOR THE ORALLY DOSED HAMSTERS, THE HALF-PERIOD OF ELIMINATION FOR 1ST COMPONENT (98% OF THE DOSE) WAS 0.29 DAYS; 2ND COMPONENT (2% OF THE DOSE) HAD A HALF-PERIOD OF 3.8 DAYS. DIFFERENCES IN THE PERCENT OF DOSE EXCRETED BETWEEN ORAL & IV DOSED HAMSTERS MAY BE DUE TO THE INCREASED FECAL EXCRETION OF ARSENIC (70%) IN THE ORALLY DOSED ANIMALS AS COMPARED TO THE IV DOSED HAMSTERS (6%).

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)|Ingestion causes irritation of stomach, weakness, other gastrointestinal symptoms. Overdose can cause arsenic poisoning, but symptoms are delayed. (USCG, 1999)|Carcinogens

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)|Get medical attention after all exposures to this compound. Be alert for arsenic poisoning symptoms. SKIN: wash well with soap and water. INGESTION: induce vomiting; drink freely lime water, milk, or raw egg; give a cathartic. (USCG, 1999)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

arsenate

Serious local effects by all routes of exposure.

Cough. Burning sensation. Sore throat. Shortness of breath. Further see Ingestion.

Redness. Pain. Skin burns.

Redness. Pain. Burns.

USEPA/OPP Pesticide Code 006801; Trade Names: Zotox; Hi-Yield Desiccant H-10; Desiccant L-10; Crab Grass Killer.|75% WT/VOL OF ARSENIC ACID OR 39.6% OF TOTAL ARSENIC EXPRESSED AS METALLIC.|Grade: Pure, technical, chemically pure|Pieces ... 99 & 99.999% purity grades; ... 75% aq solution grade

Arsenic acid (H3AsO4): ACTIVE|Pyroarsenic acid, H4As2O7, & metaarsenic acid, HAsO3, may be obtained by heating orthoarsenic acid|Formula H3AsO4, of which 52.8% is arsenic. The anhydride of this acid is arsenic pentoxide; it dissolves freely in water to yield arsenic acid.|Arsenic pentoxide is also sometimes called arsenic acid|Exists only as the hemihydrate.

MONOSODIUM METHANEARSONATE & ARSENIC ACID WERE MEASURED SIMULTANEOUS IN JOHNSONGRASS & COTTON BY BICOLORIMETRIC DETERMINATION OF THE ABSORBANCE OF THE COMPLEXES FORMED WITH SILVER DIETHYLDITHIOCARBAMATE REAGENT.

Health Hazards -> Carcinogens