D-α-Aminoadipic acid

Solid

D-2-aminoadipic acid is an optically active form of 2-aminoadipic acid having D-configuration. It has a role as a metabolite. It is an enantiomer of a L-2-aminoadipic acid.

An example of a process for the preparation of the R-3-amino-hexahydroheterocycloheptane hydrochloride of the present invention, R-3-amino-hexahydroazepine hydrochloride of the present embodiment The preparation method comprises the following steps:(1) Add 20g (124mmol) of the compound of formula I to a three-necked flask, add 200mL of methanol, add 20mL of concentrated sulfuric acid with stirring, heat to reflux, the temperature is 45 C, reaction for 2h, thin layer chromatography (TLC) detection reaction End.Cooling to room temperature, and evaporating the solvent under reduced pressure to give a colorless oil;The oil was dissolved in 220 mL of dichloromethane, and cooled to 0 C. 26.31 g of anhydrous sodium carbonate and 25.41 g of benzyl chloroformate were added successively, 220 mL of water was added under stirring, and stirring was continued at 0 C for 2 h, thin layer chromatography ( TLC) detects the end of the reaction.After the reaction was completed, the layers were allowed to stand. The organic phase is washed with water, dried over anhydrous sodium sulfate and concentrated by rotary evaporation to give the crude compound of formula II.

Widely used in biochemical and pharmaceutical fields

Molecular Weight:161.16
XLogP3:-3.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:161.06880783
Monoisotopic Mass:161.06880783
Topological Polar Surface Area:101
Heavy Atom Count:11
Complexity:157
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes