Uranium hexafluoride

352.0193292

352.041

232-028-6

1250

2977|2978

DTXSID4074566

Volatile white monoclinic crystalline solid|White crystalline solid|Deliquescent

0

-17.97600

Radioactive material, uranium hexafluoride, fissile appears as a colorless volatile white crystalline solid. Highly toxic and corrosive. Radioactive. Emits high energy rays which may be harmful and are detectable only by special instruments. Chemically irritates skin, eyes and mucous membranes. Used to make fuel for nuclear power plants.

5.09 g/cm³ @ Temp: 20.7 °C

65 °C

56 °C

soluble liquid Cl2, Br2; gives dark red fuming solution with nitrobenzene; soluble CCl4, CH3Cl [MER06]

115 mm Hg at 25 deg C

12 at BP of >uranium hexafluoride (Air= 1)

Deliquesent; decomposes in alcohol, ether, cold water|Triple point: 64.0 °C at 1134 mm Hg|Vapor behaves nearly as a perfect gas.|Heat of formation = -2158.9 kJ/mol at 25 °C (solid); heat of fusion = 19.196 kJ/mol at 64.01 °C; heat of sublimation = 48.095 kJ/mol at 64.01 °C|For more Other Experimental Properties (Complete) data for URANIUM HEXAFLUORIDE (9 total), please visit the HSDB record page.

Reacts vigorously with water to form uranyl fluoride (UO2F2) and corrosive hydrogen fluoride (hydrofluoric acid). Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Fluoride gas will be created in 1.2 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Fluoride Salts, Soluble

Water-Reactive

URANIUM HEXAFLUORIDE [FISSILE, CONTAINING MORE THAN 1% U-235] has been enriched in the fissile isotope of uranium. Naturally occurring uranium contains 0.7% U-235 (higher radioactivity) and 99.3% U-238 (lower radioactivity). Emits fumes of highly toxic metallic uranium and uranium fluorides when heated to decomposition [Lewis, 3rd ed., 1993, p. 1301]. Reacts vigorously with aromatic hydrocarbons (benzene, toluene, xylenes), undergoes a violent reaction with water or alcohols (methanol, ethanol) [Bretherick, 5th ed., 1995, p. 1439]. Reacts with most metals.|URANIUM HEXAFLUORIDE in which the uranium has been depleted of the isotope U-235. Naturally occurring uranium contains 0.7% U-235 and 99.3% U-238 (lower radioactivity). Thus, a depleted uranium material with some U-235 removed by the enrichment process is less radioactive. Emits fumes of highly toxic metallic uranium and uranium fluorides when heated to decomposition [Lewis, 3rd ed., 1993, p. 1301]. Reacts vigorously with aromatic hydrocarbons (benzene, toluene, xylenes), undergoes a violent reaction with water or alcohols (methanol, ethanol) [Bretherick, 5th ed., 1995, p. 1439]. Reacts with most metals.

Uranium hexafluoride will attack some forms of plastics, rubber, and coatings.|Highly corrosive

28.899 kJ/mol at 64.01 °C

Critical temperature: 230.2 °C; Critical pressure: 45.5 atm

7

2978

26/28-33-51/53

(1/2)-20/21-45-61

YR4720000

T+, N

Store only in original container. Separated from acids and organic compounds. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

Volatile crystals

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Disposal of ... wastes /containing uranium/ should follow guidelines set forth by the Nuclear Regulatory Commission. /Uranium and compounds/

Reacts vigorously with water, forming mainly uranyl fluoride and hydrofluoric acid.|Interaction with benzene, toluene, or xylene is very vigorous, with separation of carbon, and violent with ethanol or water.|Reacts vigorously with ... alcohol, ether ...|Uranium may ignite or explode during dissolution in bromine trifluoride, particularly when high concentrations of the hexafluoride are present.|For more Hazardous Reactivities and Incompatibilities (Complete) data for URANIUM HEXAFLUORIDE (6 total), please visit the HSDB record page.

DHHS/ATSDR; Toxicological Profile for Uranium (PB/99/163362) (September 1999)|Just RA; Report on Toxicological Studies Concerning Exposures to Uranium Hexafluoride and Uranium Hexafluoride Hydrolysis Products (1984)

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: Substance does not burn. The material may react violently with fuels. Product will decompose to produce toxic and/or corrosive fumes. Containers in protective overpacks (horizontal cylindrical shape with short legs for tie-downs), are identified with "AF", "B(U)F" or "H(U)" on shipping papers or by markings on the overpacks. They are designed and evaluated to withstand severe conditions including total engulfment in flames at temperatures of 800°C (1475°F) for a period of 30 minutes. Bare filled cylinders, identified with UN2978 as part of the marking (may also be marked H(U) or H(M)), may rupture in heat of engulfing fire; bare empty (except for residue) cylinders will not rupture in fires. Radioactivity does not change flammability or other properties of materials. (ERG, 2016)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.|Reactive - 1st degree

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: As an immediate precautionary measure, isolate spill or leak area for at least 25 meters (75 feet) in all directions. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2977 datasheet. FIRE: When a large quantity of this material is involved in a major fire, consider an initial evacuation distance of 300 meters (1000 feet) in all directions. (ERG, 2016)|Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: As an immediate precautionary measure, isolate spill or leak area for at least 25 meters (75 feet) in all directions. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 2978 datasheet. FIRE: When a large quantity of this material is involved in a major fire, consider an initial evacuation distance of 300 meters (1000 feet) in all directions. (ERG, 2016)

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: Do not touch damaged packages or spilled material. DO NOT GET WATER INSIDE CONTAINERS. Without fire or smoke, leak will be evident by visible and irritating vapors and residue forming at the point of release. Use fine water spray to reduce vapors; do not put water directly on point of material release from container. Residue buildup may self-seal small leaks. Dike far ahead of spill to collect runoff water. (ERG, 2016)

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)|Employees should be provided with & required to use impervious clothing, gloves, face shields (eight in minimum) ... to prevent any possibility of skin contact with solids or liquids containing uranium hexafluoride.|Wear appropriate personal protective clothing to prevent skin contact. /Uranium (soluble compounds, as U)/|Wear appropriate eye protection to prevent eye contact. /Uranium (soluble compounds, as U)/|Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. (Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.) /Uranium (soluble compounds, as U)/|For more Personal Protective Equipment (PPE) (Complete) data for URANIUM HEXAFLUORIDE (8 total), please visit the HSDB record page.

Finely divided U metal and some U compounds may ignite spontaneously in air or oxygen. /Uranium compounds/

/In fighting fires wear/ self-contained breathing apparatus with full facepiece operated in pressure-demand or other positive pressure mode.

Uranium hexafluoride is removed from a uranium refining waste gas by sorption with a hydrocarbon noncombustible oil, eg poly(trifluorochloroethylene). Waste gas containing 0.01 g uranium hexafluoride was scrubbed with 10 L of 10% poly(trifluorochloroethylene) to give 90% removal of uranium hexafluoride.

The potential for release of gaseous UF6, and subsequent generation of its soluble hydrolysis product UO2F2, requires special air-sampling considerations in uranium conversion and gaseous diffusion plants, relative to those plants handling less reactive compounds. In these plants, effective processing, as well as worker safety, requires a high degree of containment.|... If employees' clothing may have become contaminated ... change into uncontaminated clothing. ... Clothing which has had any possibility of being contaminated with uranium hexafluoride or clothing contaminated with other soluble uranium compounds should be placed in closed containers for storage until it can be discarded or until provision is made for the removal of soluble uranium compounds from the clothing. ... Where there is any possibility of exposure of employees's body to solids or liquids containing uranium hexafluoride, facilities for quick drenching of the body should be provided. ... Eye-wash fountains should be provided within the immediate work area for emergency use. Skin that becomes contaminated with uranium hexafluoride should be immediately washed or showered. ...|Best handled in copper apparatus.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers.|For more Preventive Measures (Complete) data for URANIUM HEXAFLUORIDE (16 total), please visit the HSDB record page.

If ... THERE IS NO FIRE, go directly to the Table of Initial Isolation and Protective Action Distances /(see table below)/ ... to obtain initial isolation and protective action distances. IF THERE IS A FIRE, or IF A FIRE IS INVOLVED, go directly to the appropriate guide /(see guide(s) below)/ and use the evacuation information shown under PUBLIC SAFETY. /Radioactive material, Uranium hexafluoride; Radioactive material, Uranium hexafluoride, fissile; Radioactive material, Uranium hexafluoride, non-fissile or fissile-excepted; Uranium hexafluoride; Uranium hexafluoride, fissile containing more than 1% Uranium-235; Uranium hexafluoride, fissile-excepted; Uranium hexafluoride, low specific activity; Uranium hexafluoride, non-fissile/|/GUIDE 166: RADIOACTIVE MATERIALS - CORROSIVE (URANIUM HEXAFLUORIDE/WATER-SENSITIVE)/ Health: Radiation presents minimal risk to transport workers, emergency response personnel and the public during transportation accidents. Packaging durability increases as potential radiation and criticality hazards of the content increase. Chemical hazard greatly exceeds radiation hazard. Substance reacts with water and water vapor in air to form toxic and corrosive hydrogen fluoride gas and an extremely irritating and corrosive, white-colored, water-soluble residue. If inhaled, may be fatal. Direct contact causes burns to skin, eyes, and respiratory tract. Low-level radioactive material; very low radiation hazard to people. Runoff from control of cargo fire may cause low-level pollution. /Radioactive material, Uranium hexafluoride; Radioactive material, Uranium hexafluoride, fissile; Radioactive material, Uranium hexafluoride, non-fissile or fissile-excepted; Uranium hexafluoride; Uranium hexafluoride, fissile containing more than 1% Uranium-235; Uranium hexafluoride, fissile-excepted; Uranium hexafluoride, low specific activity; Uranium hexafluoride, non-fissile/|/GUIDE 166: RADIOACTIVE MATERIALS - CORROSIVE (URANIUM HEXAFLUORIDE/WATER-SENSITIVE)/ Fire or Explosion: Substance does not burn. The material may react violently with fuels. Containers in protective overpacks (horizontal cylindrical shape with short legs for tie-downs), are identified with "AF", "B(U)F" or "H(U)" on shipping papers or by markings on the overpacks. They are designed and evaluated to withstand severe conditions including total engulfment in flames at temperatures of 800 °C (1475 °F). Bare filled cylinders, identified with UN2978 as part of the marking (may also be marked H(U) or H(M)), may rupture in heat of engulfing fire; bare empty (except for residue) cylinders will not rupture in fires. Radioactivity does not change flammability or other properties of materials. /Radioactive material, Uranium hexafluoride; Radioactive material, Uranium hexafluoride, fissile; Radioactive material, Uranium hexafluoride, non-fissile or fissile-excepted; Uranium hexafluoride; Uranium hexafluoride, fissile containing more than 1% Uranium-235; Uranium hexafluoride, fissile-excepted; Uranium hexafluoride, low specific activity; Uranium hexafluoride, non-fissile/|/GUIDE 166: RADIOACTIVE MATERIALS - CORROSIVE (URANIUM HEXAFLUORIDE/WATER-SENSITIVE)/ Public Safety: CALL Emergency Response Telephone Number ... . Priorities for rescue, life-saving, first aid, fire control and other hazards are higher than the priority for measuring radiation levels. Radiation Authority must be notified of accident conditions. Radiation Authority is usually responsible for decisions about radiological consequences and closure of emergencies. As an immediate precautionary measure, isolate spill or leak area for at least 25 meters (75 feet) in all directions. Stay upwind. Keep unauthorized personnel away. Detain or isolate uninjured persons or equipment suspected to be contaminated; delay decontamination and cleanup until instructions are received from Radiation Authority. /Radioactive material, Uranium hexafluoride; Radioactive material, Uranium hexafluoride, fissile; Radioactive material, Uranium hexafluoride, non-fissile or fissile-excepted; Uranium hexafluoride; Uranium hexafluoride, fissile containing more than 1% Uranium-235; Uranium hexafluoride, fissile-excepted; Uranium hexafluoride, low specific activity; Uranium hexafluoride, non-fissile/|For more DOT Emergency Guidelines (Complete) data for URANIUM HEXAFLUORIDE (9 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

A corrosive irritant to skin, eyes, and mucous membranes.

Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 0.6 mg/cu m. /Uranium (insoluble compounds, as U)/

Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Vacuum with specialist equipment or carefully sweep into dry or sealable containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Store only in original container. Separated from acids and organic compounds. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

Corrosive. Inhalation may cause severe swelling of the throat. This may result in asphyxia. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. Exposure at high levels could cause death. Exposure could cause severe lung damage. Medical observation is indicated.

Cumulative effects are possible.

AVOID ALL CONTACT! PREVENT DISPERSION OF DUST! IN ALL CASES CONSULT A DOCTOR!

Use closed system, ventilation and breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

D003; A waste containing uranium hexafluoride may (or may not) be characterized a hazardous waste following testing for the reactivity characteristics as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations.

D003; A solid waste containing uranium hexafluoride may become characterized as a hazardous waste when subjected to testing for reactivity as stipulated in 40 CFR 261.23, and if so characterized, must be managed as a hazardous waste.

LC50 Rats inhalation 26,098 mg U/cu m for 5-minute exposure|LC50 Guinea pigs inhalation 35,011 mg U/cu m for a 2-minute exposure limit.

Populations susceptible to uranium toxicosis would include people with impaired renal function. People with stomach ulcers are thought to have elevated absorption of some toxic metals and might be unusually susceptible to uranium toxicity.|Humans who excrete acidic urine may be more sensitive to uranium-induced kidney injury.

ATMOSPHERIC FATE: Most uranium compounds are ionic in nature and would generally have extremely low vapor pressures(SRC). These compounds are expected to exist in the ambient atmosphere in the particulate phase(SRC). One exception to this is uranium(VI) hexafluoride, which has a vapor pressure of 115 mm Hg at 25 °C(1). Uranium compounds in the particulate-phase will be removed from the atmosphere by wet or dry deposition(SRC).

... Uranium present in the (6+) oxidation state is highly mobile. ... /Hexavalent uranium/

Inhalation of fume, dust, or gas, ingestion, skin, & eye contact. The following uranium salts are reported to be capable of penetrating intact skin: uranyl nitrate, UO2(NO3)2.6H2O; uranyl fluoride, UO2F2; uranium pentachloride, UCl5; uranium trioxide (uranyl oxide) ... uranium hexafluoride, UF6.|THE RELEASE OF URANIUM HEXAFLUORIDE & ITS HYDROLYSIS PRODUCTS INTO THE WORK ENVIRONMENT OF A PLANT FOR ENRICHING URANIUM BY MEANS OF GAS CENTRIFUGES IS DISCUSSED. THE MAX PERMISSIBLE MASS & CURIE CONCN OF AIRBORNE URANIUM IS IDENTIFIED AS FUNCTION OF ENRICHMENT LEVEL (IE (235)URANIUM/TOTAL URANIUM), & CHEM & PHYSICAL FORM. THE CHEM & RADIOLOGICAL TOXICITY OF URANIUM AS FUNCTION OF ENRICHMENT & CHEM FORM IS GIVEN.|The following uranium salts are reported to be capable of penetrating intact skin: uranyl nitrate, uranyl fluoride, uranium pentachloride, uranium trioxide and uranium hexafluoride(1).|In the 1940s, an accident involving the sudden release of gaseous uranium fluoride resulted in the death of two people, serious injury of three others, and minor injury to 13 others(1). Those affected experienced renal lesions and diffuse inflammatory changes in the lungs and gastrointestinal tract. The renal damage was thought to be caused by adsorbed uranium while skin, eye and respiratory effects were attributed to the direct action of fluorine(1). In another study, the exposure to an accidental release of uranium fluoride and its hydrolysis products to 31 workers in 1986 was investigated. The study indicated that none of the 31 workers sustained any observable health effects from exposure to uranium even though an exposure limit of 9.6 mg was exceeded by eight of the workers(1).

Daily urinary excretion of uranium by workers chronically inhaling dust from uranium and other uranium compounds was 10-40 mg/worker, with occasional peaks of 100-200 mg. Most of the time, the radioactivity at work places fluctuated from 60 picoCi/cu m (max permissible concn) & 190 picoCi/cu m. correlation between the air radioactivity and urinary uranium excretion was frequently disturbed by workers leaving the work place or wearing protective masks. Urinary elimination of uranium hexafluoride in workers lasted 48 hr.|Uranium hexafluoride is highly transportable in the body. /From table/|Inhalation Classification - Uranium hexafluoride - Class "D" most transportable (pulmonary removal half-time of days) /Table/|Urinalysis results obtained following 4 incidents in which 13 workers were exposed to airborne triuranium octaoxide, uranium hexafluoride, & uranium ore concn showed urinary uranium concentrations of less than or equal to 2.85 mg uranium/L. /Uranium compounds/|For more Absorption, Distribution and Excretion (Complete) data for URANIUM HEXAFLUORIDE (9 total), please visit the HSDB record page.

...After inhaling uranium hexafluoride particles, humans during the first day excrete in urine approximately 73% of the solubilized uranium from the lung, with a biological half-life of approximately 4 hours, and another 10% with a half-life of 1.3 days. In a second stage of slower excretion, abiological half-life of approximately 6 days is estimated by the second day or later.|The biologic half times of soluble uranium compounds (e.g., uranium hexafluoride, uranyl fluoride, uranium tetrachloride, uranyl nitrate hexahydrate) are estimated in days or weeks. /Soluble uranium compounds/

Compared to other heavy metals, such as cadmium, lead, and mercury ... uranium's nephrotoxic effect is less intense. Although the nephrotoxicity of uranium is attributed primarily to its metallotoxicity (chemical toxicity), some authors have discussed that renal damage from exposure to high-LET alpha-emitting heavy metals, like uranium, is derived from combined chemical and radiotoxic effect. /Uranium NOS/|Approximately 60% of uranium absorbed into the blood is transported in the form of a bicarbonate complex, and 40% is bound to plasma proteins. The uranyl-bicarbonate complex is filtered out of the blood by the renal glomerulus and is passed into the tubules. The pH of urine decreases in the tubules, resulting in dissociation of the complex and release of the reactive uranyl ion. Nephrotoxicity results primarily from damage to the tubular epithelium, which allows leakage of glucose, protein, aminoacids, and enzymes into the urine. In high doses (more than 6 mg uranium/kg), glomerular damage may also occur, causing decreased renal blood flow and a decreased glomerular filtration rate. The kidney responds to toxic levels of uranium within 24-48 hr after exposure. The changes become progressively more severe over approximately a 5 day period. The damaged tubular epithelium regenerates quickly as the uranium concentration is reduced. /Soluble uranium compounds/

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: Radiation presents minimal risk to transport workers, emergency response personnel and the public during transportation accidents. Packaging durability increases as potential radiation and criticality hazards of the content increase. Chemical hazard greatly exceeds radiation hazard. Substance reacts with water and water vapor in air to form toxic and corrosive hydrogen fluoride gas and an extremely irritating and corrosive, white-colored, water-soluble residue. If inhaled, may be fatal. Direct contact causes burns to skin, eyes, and respiratory tract. Low-level radioactive material; very low radiation hazard to people. Runoff from control of cargo fire may cause low-level pollution. (ERG, 2016)

Excerpt from ERG Guide 166 [Radioactive Materials - Corrosive (Uranium Hexafluoride / Water-Sensitive)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Call 911 or emergency medical service. Medical problems take priority over radiological concerns. Use first aid treatment according to the nature of the injury. In case of contact with Hydrofluoric acid (UN1790), flush with large amounts of water. For skin contact, if calcium gluconate gel is available, rinse 5 minutes, then apply gel. Otherwise, continue rinsing until medical treatment is available. For eyes, flush with water or a saline solution for 15 minutes. Do not delay care and transport of a seriously injured person. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Keep victim calm and warm. (ERG, 2016)

Fresh air, rest. Half-upright position. Refer immediately for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Wear protective gloves when administering first aid. Apply calcium gluconate to the burn areas. Refer immediately for medical attention.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... Perform routine emergency care for associated injuries. For eye contamination, flush eyes immediately with water. Irrigate each eye continuously during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a good gag reflex, and does not drool ... Perform routine BLS care as necessary. /Radioactives I, II, and III/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W. Use lactated Ringer's to support vital signs if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... Treat seizures with diazepam (Valium) ... Use proparacaine hydrochloride to assist eye irrigation ... /Fluorine and related compounds/|Monitoring of accidental uranium exposures and its effects on the kidney is accomplished by measurement of the uranium excreted in the urine and abnormalities in the clinical urinalyses . Glucose and albumin in urine are among the most sensitive indicators of kidney damage. ...Urinary excretion of gamma-glutamyltransferase /has been found/ to be the most sensitive indicator. These various indicators of renal injury can be assessed within a few hours of exposure to dose levels of at least 0.1 mg of uranium/kg.|Daily urine samples should be collected after large accidental exposures, and collection should continue for at least 2 weeks. The collection of 24 hr urine samples whenever possible is advantageous. These samples will be used for measuring uranium excretion and for clinical urinalysis. Bacterial degradation of glucose and other constituents of urine can be prevented by the addition of sodium azide to the sample or by immediate cooling of the sample to 5 °C. If analysis for amino acid of enzymes is to be performed later, freezing the sample at -40 °C is advisable. Quantitative measurement of glucose and protein in the urine is preferable to the usual qualitative analyses. Quantitative measurement of glucose and protein in the serum should also be performed. Serum creatinine and creatinine clearance studies are needed to assess glomerular function. Clearance tests amy underestimate filtration rate if tubular injury is present.|For more Antidote and Emergency Treatment (Complete) data for URANIUM HEXAFLUORIDE (11 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Accidental exposure of workers to a mixture of uranium hexafluoride, uranium oxyfluoride, hydrofluoric acid, and live steam caused lacrimation, conjunctivitis, shortness of breath, paroxysmal cough, rales in the chest, nausea, vomiting, skin burns, transitory albuminaria, and elevation of blood urea nitrogen. ... Injurious effects ... on skin, eyes, and resp tract apparently caused by irritant action of fluoride ion ... uranium responsible for transient renal changes. /Uranium fluorides/|/SIGNS AND SYMPTOMS/ In ... a case of accidental exposure to UF6, important findings were related to the eyes (chem conjunctivitis & corneal necrosis), the respiratory tract (incr density of bronchovascular markings and hilar shadows), and the urinary tract (incr amt of urinary solids). In 5 days with treatment, the corneal epithelium had almost completely regenerated, and at time of discharge, visual acuity was normal. In 10 days the chest was clear; in 13 days the hemorrhages of the larynx had disappeared. The urinary signs cleared with improvement of the patient. Some mental derangement, restlessness, and nervous tension accompanied the early responses, but these disappeared in 1 wk.|/SIGNS AND SYMPTOMS/ ... Dermatitis has occurred as a result of handling uranium hexafluoride.|/SIGNS AND SYMPTOMS/ Symptoms of fluoride intoxication, usually occurring within 1 hr, range from salivation, abdominal pain, nausea, vomiting, & diarrhea in cases of minor poisoning, to hyperactive reflexes, tonic & clonic convulsions, & ultimately, in severe cases, death occurs, usually from respiratory or cardiac failure. /Fluorides/|For more Human Toxicity Excerpts (Complete) data for URANIUM HEXAFLUORIDE (13 total), please visit the HSDB record page.

uranium fluoride (UF6)

Serious local effects and systemic effects by all routes of exposure.

Cough. Burning sensation. Shortness of breath. Laboured breathing.

Redness. Pain. Serious skin burns.

Pain. Severe deep burns.

A wide variety of chemical forms of uranium may be encountered. The three that will be most commonly found in industry are yellowcake uranium, uranium oxide (U3O8), and uranium hexafluoride (UF6). Yellowcake is the semirefined product from the milling of uranium and contains more than 80% uranium oxide. ...Uranium oxides are UO2, UO3, UO, U2O5, and U3O8. Uranium carbides are UC (uranium monocarbide), UC2 (dicarbide), and U2C3 (sesquicarbide). Uranium metal reacts with nitrogen to yield nitrides: UN, U2N3, and UN2. Uranium nitrides and uranium carbides are semimetallic and, when ignited in air, convert to U3O8.

Uranium fluoride (U2F9): INACTIVE|The chemical toxicity and reactive properties of any uranium compound must be weighed against the inherent toxicity of the compound or the uranium alone. For example, gaseous uranium hexafluoride (UF6) reacts with atmospheric moisture and undergoes hydrolysis, producing uranyl fluoride (UO2F2) and hydrogen fluoride (HF), a highly corrosive and toxic gas. Depending on the temperature, humidity, and uranium enrichment, the HF may be a more serious health and safety concern than either the UF6 or the contained uranium.|In uranium processes that create fluoride compounds (UF4, UF6, etc.), the a-n reaction with this light nuclide can result in neutron radiation fields, the intensity of which are a function of the compound, mixing, storage configuration, and enrichment. As indicated in Section 2.0, low enriched UF6 (< 5%) in large storage containers can result in neutron radiation in the 0.2 mrem/h range, while highly enriched (> 97%) UF6 can create fields in the 4 mrem/h range. At high enrichments, the neutron fields can be up to a factor of 2 higher than the gamma fields and be the limiting source of whole body exposure. /Uranium fluorides/|This study conducted to characterize solid products formed from release of uranium hexafluoride. Explosive release of uranium hexafluoride was conducted in a vessel in which the air at atm pressure was static & the particulate material was collected on microscope grids by gravitational settling. Transmission & sem were used to detect the size or range of sizes of the particles produced from the release & the nature of agglomerates produced from these particles.|Uranium is a chemical hazard as well as a radiological hazard.

Fluorides (eg, uranium hexafluoride) in air are photometrically detected with an apparatus with a vertical air passage duct equipped with a flow regulator, a flow meter, a unit containing a transparent bedding material (eg, silicon dioxide), & an air pump, in sequence. The magnitude of light transmitted through the material during & after passage of the fluoride-contaminated air is monitored & compared with std value.

Fire Hazards -> Reactive - 1st degree