Sodium arsenite (NaAsO2)

129.91

130.90900

231-148-6

48OVY2OC72

1603

1686|2027

DTXSID5020104

C91098

White or grayish-white powder

28429080

40.13000

-0.50590

off-white to gray powder

1.87 g/cm³

817 °C(lit.)

613 °C(lit.)

Miscible with water. Slightly miscible with alcohol.

Protect container against physical damage. Store in well ventilated area away from food or food products and combustible materials. /Inorganic arsenic cmpd/

Oral-Rat  LD50: 41 mg/kg; Abdominal cavity-mouse LD50: 1.17 mg/kg

Non-combustible substance; emits toxic arsenide vapors when exposed to heat

SALTY TASTE

Somewhat hygroscopic; absorbs CO2 from air|Arsenites are more soluble and more rapidly toxic than other forms of arsenic. /Arsenites/|ARSENITES OF ALKALI METALS ARE SLOWLY CONVERTED IN SOLN TO ARSENATES BY ATMOSPHERIC OXYGEN; & DECOMPOSED BY ATMOSPHERIC CARBON DIOXIDE

No rapid reaction with air. No rapid reaction with water.

Salts, Basic

SODIUM ARSENITE solution is basic. Absorbs carbon dioxide from the air. (NTP, 1992)

III

8

UN 1558 6.1/PG 2

3

23/25-50/53-51/53-45-52/53-22-23/24/25-21-34

20/21-28-45-60-61-53-36/37-36/37/39-26

CG0525000

T,N

Treasury is ventilated, low temperature and dry; stored separately from alkali, acid and food additives

Stable. Incompatible with strong oxidizing agents, strong acids. Protect from moisture. Absorbs carbon dioxide from air.

Missing Phrase - N15.00950417-P201-P261-P280-P308 + P313

H301-H332-H350-H411

Storage: To convert the gas-cleaning residues obtained during the metallurgical processing of arsenic-containing ores into a portable and less water-soluble form, the metals are precipitated as hydroxides by using an excess of lime water and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal. Arsenic trioxide is removed from waste gases by means of electrostatic separators (efficiency 70-90%) or bag filters (efficiency up to 99%). Bag filters, however, require twice to three times as much energy as electrostatic separators. The following storage possibilities are available today for arsenic residues that cannot be recycled immediately or at all /hazardous waste landfill/.|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/|Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS ARSENIC, IRON, ALUMINUM, ZINC, ... HIGHLY TOXIC FUMES OF ARSENIC /INCLUDING ARSINE ARE RELEASED/. /ARSENIC CMPD/|Strong oxidizers, bromide azide [Note: Hydrogen gas can react with inorganic arsenic to form the highly toxic gas arsine.] /Arsenic (inorganic compounds, as As)/

WHO; Environmental Health Criteria Document No. 224: Arsenic and arsenic compounds. EHC are designed for scientists and administrators responsible for the establishment of safety standards and regulations and provide basic scientific risk evaluations of a wide range of chemicals and groups of chemicals.[Available from, as of June 24, 2009: http://www.inchem.org/pages/ehc.html]|DHHS/ATSDR; Toxicological Profile for Arsenic (7440-38-2) (PB/2008/100002) (August 2007). The ATSDR toxicological profile identifies and reviews the key literature that describes a hazardous substance's toxicologic properties. Other pertinent literature is presented in less detail.[Available from, as of June 22, 2009: http://www.atsdr.cdc.gov/toxpro2.html]|Nat'l Research Council Canada; Effects of Arsenic in the Canadian Environment p.115 (1978) NRCC No. 15391|USEPA; Ambient Water Quality Criteria Doc: Arsenic p.37 (1984) EPA 440/5-84-033|For more Special Reports (Complete) data for SODIUM ARSENITE (7 total), please visit the HSDB record page.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H300+H310 (33.04%): Fatal if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]|P201, P202, P261, P262, P264, P270, P271, P273, P280, P281, P301+P310, P302+P350, P302+P352, P304+P340, P308+P313, P310, P311, P312, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 115 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P301+P310, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P311, P314, P321, P330, P363, P403+P233, P405, and P501|P201, P202, P260, P262, P264, P270, P280, P281, P301+P310, P302+P350, P305+P351+P338, P307+P311, P308+P313, P310, P314, P321, P322, P330, P337+P313, P361, P363, P405, and P501|P201, P202, P260, P261, P262, P264, P270, P271, P280, P281, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P307+P311, P308+P313, P310, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)|Workers should be supplied with suitable protective clothing, protective boots and when there is a risk that the exposure limit for airborne arsenic will be exceeded, respiratory protective equipment. /Arsenic cmpd/|Where there is occupational exposure to inorganic arsenic compounds, protective clothing shall be provided by the employers. This may include underwear, gloves, coveralls, and a hood over the head and neck. /Inorganic arsenic/|Wear appropriate personal protective clothing to prevent skin contact. /Arsenic (inorganic cmpd, as As)/|Wear appropriate eye protection to prevent eye contact. /Arsenic (inorganic cmpd, as As)/|For more Personal Protective Equipment (PPE) (Complete) data for SODIUM ARSENITE (7 total), please visit the HSDB record page.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources. /Sodium arsenite, solid/|If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/|If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/|Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Arsenical cmpd, solid, NOS/

Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.|Water spill: Add calcium hypochlorite. Neutralize with agricultural lime, crushed limestone, or sodium bicarbonate. Add ferric chloride. Adjust pH to neutral (pH 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.|Air spill: Apply water spray or mist to knock down vapors.|Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.|For more Cleanup Methods (Complete) data for SODIUM ARSENITE (6 total), please visit the HSDB record page.

If material not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary. /Sodium arsenite, solid/|Personnel protection: Keep upwind. Avoid breathing dusts, and fumes from burning material. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. /Sodium arsenite, solid/|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|For more Preventive Measures (Complete) data for SODIUM ARSENITE (23 total), please visit the HSDB record page.

/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Sodium arsenite, solid/|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. /Sodium arsenite, solid/|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at lease 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. /Sodium arsenite, solid/|/GUIDE 151: SUBSTANCES - TOXIC (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Sodium arsenite, solid/|For more DOT Emergency Guidelines (Complete) data for SODIUM ARSENITE (16 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritating to the eyes.|Trivalent arsenic compounds are corrosive to the skin. /Trivalent arsenic cmpd/|ARSENICAL DUSTS ... ARE IRRITATING TO UPPER RESP TRACT & EYES. CONJUNCTIVITIS PRODUCED BY ... THESE SUBSTANCES ARE CHARACTERIZED BY ITCHING, BURNING, & WATERING OF EYES. ... /INORGANIC ARSENIC DUSTS/

8 hr Time-Weighted avg: 10 ug/cu m./Arsenic, inorganic cmpd (as As)/|Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

5 mg/cu m (as As); NIOSH considers arsenic (inorganic cmpd, as As) to be a potential occupational carcinogen. /Arsenic (inorganic cmpd, as As)/|Recommended Exposure Limit: 15 Ceiling Limit: (0.002 mg/cu m). /Arsenic (inorganic cmpd, as As)/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Arsenic (inorganic compounds, as As)/

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Vacuum spilled material with specialist equipment. Sweep spilled substance into covered sealable, plastic containers. Carefully collect remainder. Then store and dispose of according to local regulations.

Store in an area without drain or sewer access. Well closed. Dry. Separated from acids, strong oxidants and food and feedstuffs.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the cardiovascular system, nervous system, gastrointestinal tract and kidneys. This may result in severe gastroenteritis, loss of fluids and electrolytes, kidney impairment, cardiac disorders, collapse and shock. Exposure could cause death. The effects may be delayed. Medical observation is indicated.

Repeated or prolonged contact with skin may cause dermatitis and pigmentation disorders. The substance may have effects on the peripheral nervous system, cardiovascular system, bone marrow, kidneys, liver and mucous membranes. This may result in neuropathy, cardiovascular disorders, lesions of blood cells, kidney impairment, cirrhosis and perforation of the nasal septum. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN! IN ALL CASES CONSULT A DOCTOR!

Use closed system or ventilation.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Sodium arsenite is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/|For more Atmospheric Standards (Complete) data for SODIUM ARSENITE (6 total), please visit the HSDB record page.

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).|Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Sodium arenite is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

LAKE LANSING WAS TREATED WITH SODIUM ARSENITE FOR CONTROL OF AQUATIC MACROPHYTES IN 1957. TWO 2.5 M SEDIMENT CORES FROM DEEP PORTIONS OF THE LAKE BASIN WERE ANALYZED FOR TOTAL ARSENIC IN 5 CM INCREMENTS. 17-20 UG/G DRY WEIGHT OCCURRED IN LOWER PORTIONS OF THE CORES, AND THIS WAS TAKEN AS BACKGROUND. BOTH CORES HAD MAXIMA OF 330-340 UG/G AT DEPTH INTERVAL 0.15-0.30 M. THESE PEAKS WERE TAKEN TO REPRESENT CONTAMINATION FROM WEED TREATMENT IN 1957. THE RATE OF DECREASE IN RECENTLY DEPOSITED SEDIMENTS PREDICTED THAT CONCENTRATIONS NEAR BACKGROUND WOULD EXIST IN SURFICIAL SEDIMENTS IN THE DEEP PORTIONS OF THE BASIN BY 1989.

In a plant where sodium arsenite was being manufactured, mean air arsenic concentrations of between 0.078 and 1.034 mg/cu m were found among various workstations during sampling times of "10 minutes or more".

most toxic

... /THE/ PROTECTIVE EFFECT OF ARSENIC AGAINST SELENIUM POISONING /WAS FOUND WHEN/ SODIUM ARSENITE (5 PPM) IN DRINKING WATER REDUCED LIVER DAMAGE IN RATS ON DIET CONTAINING SELENIUM @ 15 PPM IN SELENIFEROUS WHEAT. ... SODIUM ARSENITE ... MOST EFFECTIVE IN ENHANCING BILIARY EXCRETION OF SELENIUM ... .|THE IP ADMIN OF THE SODIUM SALT OF 2,3-DIMERCAPTO-1-PROPANESULFONIC ACID OR MESO-DIMERCAPTOSUCCINIC ACID (DMSA) (0.80 MMOL/KG) IMMEDIATELY AFTER AND 90 MINUTES AFTER SODIUM ARSENITE INCREASED THE LD50 OF SODIUM ARSENITE 2-FOLD, RESPECTIVELY. D-PENICILLAMINE AND N-ACETYL-DL-PENICILLAMINE DID NOT AFFECT THE LD50 UNDER THE SAME CONDITIONS. A SERIES OF POLYMERCAPTO COMPOUNDS, SOME HAVING AS MANY AS 4 MERCAPTO GROUPS PER MOLECULE, ALSO DID NOT PROTECT AGAINST SODIUM ARSENITE. THERE IS EXTENSIVE EXPERIMENTAL AND CLINICAL INFORMATION ABOUT SODIUM SALT OF 2,3-DIMERCAPTO-1- PROPANESULFONIC ACID AND MESO-DIMERCAPOTOSUCCINIC ACID AVAILABLE IN THE SOVIET AND CHINESE LITERATURE WHERE THESE AGENTS ARE KNOWN AS UNITHIOL OR UNITHIOL AND SUCCIMER, RESPECTIVELY.|SODIUM ARSENITE (160 PPM ARSENIC) INCREASED THE INCIDENCE OF DIETHYLNITROSAMINE (30 MG/KG, IP) INITIATED KIDNEY TUMOR BY ACTING AS A PROMOTER CARCINOGEN. ARSENIC BY ITSELF DID NOT CAUSE ANY TUMORS.|meso-Dimercaptosuccinic acid, and N-(2,3-dimercapto-1-propanesulfonic acid, sodium salt, and N-(2,3-dimercaptopropyl)-pthalamidic acid are water soluble analogs of 2,3-dimercapto-1-propanol. The relative effectiveness or therapeutic index of these dimercapto compounds in protecting mice from the lethal effects of an LD99 of sodium arsenite is meso-Dimercaptosuccinic acid greater than N-(2,3-dimercapto-1-propanesulfonic acid, sodium salt greater than N-(2,3-dimercaptopropyl)-pthalamidic acid greater than 2,3-dimercapto-1-propanol, in the magnitude of 42:14:4:1, respectively. N-(2,3-dimercapto-1-propanesulfonic acid, sodium salt, N-(2,3-dimercaptopropyl)-pthalamidic acid, or meso-Dimercaptosuccinic acid will mobilize tissue arsenic. 2,3-Dimercapto-1-propanol, however increases the arsenic content of the brain of rabbits injected with sodium arsenite. These results raise the question as to the appropriateness of 2,3-dimercapto-1-propanol as the treatment for systemic arsenic poisoning. Either meso-Dimercaptosuccinic acid or N-(2,3-dimercapto-1-propanesulfonic acid, sodium when given sc or po, will protect administered Lewisite. N-(2,3-dimercapto-1-propanesulfonic acid, sodium salt and meso-Dimercaptosuccinic acid have promise as prophylactics for the prevention of the vesicant action action of Lewisite. The sodium arsenite inhibition of the pyruvate dehydrogenase (PDH) complex can be prevented and reversed in vitro or in vivo by N-(2,3-dimercapto-1-propanesulfonic, meso-Dimercaptosuccinic acid, N-(2,3-dimercaptopropul)-pthalamidic acid or 2,3-dimercapto-1-propanol. Of them all, N-(2,3-dimercapto-1-propanesulfonic acid, sodium salt is most potent and BAL appears to be the least potent.|For more Interactions (Complete) data for SODIUM ARSENITE (8 total), please visit the HSDB record page.

LD50 Rat ip 13.39 mg/kg|LD50 Rat oral 11.2 ppm. /Arsenite/|LD50 Rat oral 41 mg/kg|LD50 Rat skin 150 mg/kg|For more Non-Human Toxicity Values (Complete) data for SODIUM ARSENITE (10 total), please visit the HSDB record page.

... Sodium arsenite was ... selected for immunotoxicity studies /using female B6C3f1 mice/. The purpose of the range-finding study was to determine the doses of sodium arsenite to be used in an immuntoxicology protocol. The range-finding studies were conducted in female B6C3F1mice. The animals were administered sodium arsenite as a pellet implanted subcutaneously. ... The pellets were prepared using 1, 3 and 6 mg/pellet as recommended by the producer to obtain the desired blood levels of 100, 300 and 600 ng/ml. These doses proved highly toxic and the pellets were then prepared at 0.01, 0.03 and 0.06 mg/pellet. Two studies were carried out in completing the range-finding protocol. The pellets were implanted on day 1 and the assay evaluations were performed on day 15. Dose levels of 0.01, 0.03 and 0.06 mg/pellet were used; however, the high dose of 0.06 mg/pellet resulted in the death of the mice. ... The results of the sodium arsenite range-finding studies demonstrate that, in the female B6C3F1 mouse, exposure to sodium arsenite, administered by a subcutaneous implanted pellet for a 14-day exposure at doses of 0.06 or greater, produced overt toxicity and death of the animals. Exposure to lower doses of sodium arsenite (0.01 and 0.03 mg/pellet) did not result in significant changes in body weight, change in body weight gain, erythrocyte number, hemoglobin, hematocrit, mean corpuscular hemoglobin concentration, reticulocytes or leukocyte number. A slight, but significant decrease was seen in the mean corpuscular volume and mean corpuscular hemoglobin. Exposure to lower doses of sodium arsenite (0.01 and 0.03 mg/pellet) did not result in significant changes in liver, spleen, thymus or kidney weight when the data were expressed as absolute weight (mg) or as percent body weight. A significant decrease was seen in the lung absolute weight (22.6%) but not in the percent body weight. ... Exposure to lower doses of sodium arsenite (0.01 and 0.03 mg/pellet) did not produce significant changes in the antibody-forming cell response to the T-dependent antigen, sheep erythrocytes, expressed as IgM AFC/10, while the IgM AFC/spleen did show a significant increase at 0.03 mg/pellet (49.2%). In the surface marker absolute values, no effects were observed in the number of B cells, T cells or CD8+ cells, but a significant decrease in the CD4+ cells (12.3%) was seen. Exposure to lower doses of sodium arsenite (0.01 and 0.03 mg/pellet) did not result in significant changes in the mixed leukocyte response (MLR) or natural killer (NK) cell activity. Based on the overall negative toxicological and immunological results of this range-finding study, the test article, sodium arsenite, will not be pursued as an expanded protocol.

AS A RESULT OF APPLYING ARSENICALS AS HERBICIDES, DESICCANTS, OR SOIL STERILANTS, SOIL ARSENIC LEVELS CAN INCREASE UNDER SOME CONDITIONS. SODIUM ARSENITE WAS APPLIED TO BARE SOIL AT 1, 2, AND 10 TIMES THE RECOMMENDED MAX APPLICATION RATE. AFTER INCORPORATION, RADISHES AND SOYBEANS WERE PLANTED AS INDICATOR CROPS TO ASSESS THE PHYTOTOXICITY OF ARSENIC RESIDUES. SOIL RESIDUES INCR AT ALL LEVELS OF APPLICATION. HOWEVER, ONLY 50% OF THE ARSENIC APPLIED AT 10 TIMES THE RECOMMENDED RATE WAS FOUND AFTER 7 ANNUAL APPLICATIONS. TOTAL LOSSES OF ARSENIC FROM THE SOIL AVERAGED 14-15% OF THAT APPLIED EACH YEAR.

ENVIRONMENTAL ACCUMULATION: WHEN SODIUM ARSENITE WAS USED AS AN AQUATIC HERBICIDE IN A WISCONSIN LAKE, ELEVATED ARSENIC CONCENTRATIONS WERE FOUND IN AQUATIC VEGETATION. A SINGLE SAMPLE OF CLADOPHORA CONTAINED 1258 MG/KG ARSENIC (DRY WEIGHT), AND FRESH SHOOTS OF MATURE MYRIOPHYLLUM STEMS CONTAINED BETWEEN 228 AND 261 MG/KG (DRY WEIGHT).

Water soluble inorganic arsenicals, eg sodium arsenite, are leached toward greater depths than organic arsenicals. ... In sandy soils, 720 kg/ha applied to the soil as sodium arsenite had, after 3 yr, reached a depth of 60 cm. ... Inorganic arsenicals ... show a strong tendency to leach into surface and groundwaters.|ENVIRONMENTAL PERSISTENCE: INORGANIC ARSENICALS ... SUCH AS ... SODIUM ARSENITE ... HAVE BEEN USED FOR MANY YR AS SOIL STERILANTS ... THESE CMPD ARE MOST PERSISTENT SOIL STERILANTS & MAY REMAIN EFFECTIVE FOR PERIODS AS LONG AS 5-8 YR ESP IN AREAS OF LOW RAINFALL.

1,999 total people exposed (est) and 203 females exposed (est) from actual observed occupational use of sodium arsenite.

EXPTL THERAPY THE OPTICAL ISOMERS OF SODIUM 2,3-DIMERCAPTO-1-PROPANESULFONATE WERE SEPARATED AND THE ARSENIC ANTIDOTAL ACTIVITY OF THE L-ISOMER, THE D-ISOMER, AND THE RACEMIC MIXTURE OF 2,3-DIMERCAPTO-1-PROPANESULFONATE WERE INVESTIGATED IN VIVO AND IN VITRO.|MEDICATION (VET): TOPICAL ACARICIDE (TECHNICAL GRADE, 90-95% PURE)|MEDICATION (VET): COMPONENT OF CATTLE & SHEEP DIPS|MEDICATION (VET): EXTERNALLY, AS DIP (0.25%) AGAINST LICE & TICKS OF CATTLE, GOATS, & SHEEP. INTERNALLY, IN ORAL ELECTROLYTE MIXT, IN ANTHELMINTICS, & IN ALTERATIVE PREPN WHERE ITS READY WATER SOLUBILITY & RAPID SYSTEMIC ABSORPTION IS DESIRED.

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

Arsenite crosses the placenta.|RATE OF ABSORPTION OF INORG ARSENICALS FROM DIGESTIVE TRACT DEPENDS UPON THEIR SOLUBILITY. SODIUM ARSENITE IS READILY SOL, RAPIDLY ABSORBED.|AT 20 HR AFTER IV INJECTION OF 4 MG (76)ARSENIC AS SODIUM ARSENITE TO ONE PATIENT WITH TERMINAL CANCER, HIGHEST LEVELS OF ARSENIC WERE FOUND IN LIVER & KIDNEYS & RELATIVELY SMALLER LEVELS IN VARIOUS OTHER TISSUES. EXCRETION OF (76)ARSENIC IN THE FIRST 24 HOURS AFTER AN IV INJECTION OF LABELLED SODIUM ARSENITE TO 2 PATIENTS WITH TERMINAL CANCER WAS 16.7% OF THE INJECTED DOSE; EXCRETION WAS MAINLY VIA THE URINE.|FOLLOWING IV ADMINISTRATION OF (76)ARSENIC AS SODIUM ARSENITE TO FIVE RATS AND FOUR RABBITS, THE URINARY EXCRETION OF (76)ARSENIC IN THE FIRST 48 HOURS WAS LESS THAN 10% OF THE DOSE IN RATS AND 30% IN RABBITS. FOLLOWING IP INJECTION IN MICE, 75% OF THE DOSE WAS EXCRETED WITHIN THE FIRST 24 HOURS. IN ALL SPECIES TESTED, LESS THAN 10% OF THE TOTAL ... WAS EXCRETED IN THE FECES. UNLIKE RABBITS, RATS RETAIN MOST OF THE INJECTED DOSE IN THE BLOOD FOR A PROLONGED PERIOD. TISSUE DISTRIBUTION STUDIES REVEALED HIGHEST LEVELS OF (76)ARSENIC IN THE BLOOD AND SPLEEN OF RATS, IN THE LIVER, KIDNEYS AND LUNGS OF RABBITS AND IN THE LIVER, KIDNEYS AND SPLEEN OF MICE.|For more Absorption, Distribution and Excretion (Complete) data for SODIUM ARSENITE (9 total), please visit the HSDB record page.

The urinary metabolites of sodium arsenite have been investigated in rabbits given sodium arsenite and water-soluble dimercaptans. Rabbits injected sc with NaAsO2 (1 mg arsenic/kg) were given im 1 hr later, either saline, 2,3-dimercapto-1-propanesulfonic acid, mesodimercaptosuccinic acid, or N-(2,3-dimercaptopropyl)phthalamidic acid at 0.2 mmol/kg. Arsenic metabolites in urine collected from treated rabbits were isolated by combined anion-cation-exchange chromatography. Column fractions were acid-digested and analyzed for arsenic by direct hydride-flame atomic absorption spectrophotometry. The relative amounts of inorganic arsenic, methylarsonate, and dimethylarsinate found in 0 to 24 hr urine of rabbits given only sodium arsenite agreed closely with those reported for human subjects given arsenite po. This finding suggests that the rabbit biotransforms arsenite in a manner very similar to humans. The urinary excretion of total arsenic between 0 and 24 hr was elevated after dimercaptan administration. but urinary excretion of total arsenic between 0 and 48 hr was unaffected. This result indicates that the action of these dimercaptans occurs early after treatment. In addition, the dimercaptans influenced differently the amounts of the arsenic metabolites excreted in the urine between 0 and 24 hr. 2,3-Dimercapto-1-propanesulfonic acid, mesodimercaptosuccinic acid, or 2,3-dimercapto-1-propanesulfonic acid increased arsenite excretion but decreased dimethylarsinate excretion. 2,3-dimercapto-1-propanesulfonic acid or N-(2,3-dimercaptopropyl)phthalamidic acid treatment increased methylarsonate excretion but mesodimercaptosuccinic acid did not. Arsenate excretion increased after 2,3-dimercapto-1-propanesulfonic acid or mesodimercaptosuccinic acid, treatment but was not affected by N-(2,3-dimercaptopropyl)phthalamidic acid treatment. These results suggest that the dimercaptans, in addition to increasing arsenic excretion, also influence the biotransformation of arsenite to less toxic species. The different effects on the urinary excretion of arsenic metabolites suggest that these dimercaptan metal binding agents have mechanisms of action in addition to simple chelation of inorganic arsenic.|The fungi Candida hemicola biotransforms sodium arsenite to trimethyl arsine.|Cows and dogs were fed sodium arsenite and sodium arsenate daily for five days. Urine was collected and analyzed for methylarsenate and inorganic arsenate. In the cow, the levels rose to 0.1 to 0.5 and 1.0 to 4.0 ppm, respectively. When cows were returned to normal diets, all values returned to control levels (0.02 to 0.10 ppm and 0.1 to 0.2 ppm). In dogs, arsenite feeding produced identical peak values 5.0 to 7.0 ppm for both methylarsenate and inorganic arsenate. Feeding of sodium arsenate to dogs produced a rise to 10 ppm methylarsenate and 5.0 ppm inorganic arsenate. Six days after withdrawal from the arsenic-containing diet, all values reached control levels ... .|Mice were administered im 1.3 mg As(III)/kg after exposure to a toxic concentration of sodium arsenite (250 mg As(III)/l) for 2, 6 and 8 days. Whereas mice not exposed to the treated drinking water excreted one-half the im administered As(III), those mice previously exposed to the treated water excreted 80% of the applied As(III) as As(V) in 2 days; more than 95%, after 4 days; and after 8 days only traces of As(III) were present ... .|Cultured BALB/3T3-Cl-A31-1-1 mouse embryo cells were used to study the cytotoxicity, neoplastic transformation, and metabolic reduction or oxidation of trivalent arsenic, in the form of sodium arsenite (arsenic(3+)), and pentavalent arsenic, in the form of sodium arsenate (arsenic(5+)). Uptake of arsenic(3+) and arsenic(5+) by the cells was highest during the first hour and was dose dependent; cells treated with equimolar concn of the agents demonstrated four fold greater uptake for arsenic(3+) than for arsenic(5+). Arsenic(3+) was more cytotoxic than arsenic(5+), although no differences were apparent between the two products with respect to total arsenic in the cells. The relative transformation activity for arsenic(3+) compared to arsenic(5+) was equal to about 4:1. Arsenic(5+) showed a high rate of intracellular metabolic reduction; arsenic(5+) exposure yielded more than 70 percent arsenic(3+) in cytosol, as compared to 100 percent for arsenic(3+) exposure. Ion exchange chromatography did not detect any methylated metabolites. In cell free medium incubations, up to 30 percent of arsenic(3+) was oxidized to arsenic(5+), as compared to only 4 percent oxidation in the presence of cells. Unchanged arsenic(5+) was recovered following its incubation in cell free medium, while the presence of cells resulted in the generation of up to 5 percent arsenic(3+), in a dose dependent manner. The reduction of arsenic(5+) to arsenic(3+) by the cells was inhibited up to 25 percent by depletion of glutathione with diethylmaleate. The authors conclude that arsenic(3+) is responsible for the cytotoxic and transforming action of inorganic arsenic.

ARSENITE IS READILY ABSORBED WHEN TAKEN INTERNALLY & POISONING IS ATTRIBUTED TO RAPID DEATH OF CELLS DUE TO INHIBITION OF RESP FROM LACK OF ADENOSINE TRIPHOSPHATE.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)|Carcinogens, Teratogens

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Exptl Therapy: Meso-dimercaptosuccinic acid, 2,3-dimercapto-1-propanesulfonic acid, sodium salt, and n-(2,3-dimercaptopropyl)-phthalamidic acid, are water soluble analogs of 2,3-dimercapto-1-propanol. The relative effectiveness or therapeutic index of these dimercapto compounds in protecting mice from the lethal effect of an LD99 of sodium arsenite is meso-dimercaptosuccinic acid greater than 2,3-dimercapto-1-propanesulfonic acid, sodium salt greater than n-(2,3-dimercaptopropyl)-phthalamidic acid greater than 2,3-dimercapto-1-propanol in the magnitude of 42:14:4:1, respectively. 2,3-Dimercapto-1-propanesulfonic acid, sodium salt, n-(2,3-dimercapto-1- propanesulfonic acid, sodium salt, or Meso-demercaptosuccinic acid will mobilize tissue arsenic. 2,3-Dimercapto-1-propanol however, increases the arsenic content of the brain of rabbits injected with sodium arsenite. These results raise the question as to the appropriateness of 2,3-dimercapto-1-propanol as the treatment for systemic arsenic poisoning. Either meso-dimercaptosuccinic acid or 2,3-dimercapto-1-propanesulfonic acid, sodium salt, when given sc or orally, will protect rabbits against the lethal systemic effects of sc administered lewisite. 2,3-Dimercapto-1-propanesulfonic acid, sodium salt and meso-dimercaptosuccinic acid, have promise as prophylactics for the prevention of the vesicant action of lewisite. The sodium arsenite inhibition of the pyruvate dehydrogenase complex can be prevented and reversed in vitro or in vivo by 2,3-dimercapto-1-propanesulfonic acid, sodium salt, meso-dimercaptosuccinic acid, n-(2,3-dimercaptopropyl)-phthalamidic acid or 2,3-dimercapto-1-propanol. Of them all, 2,3-dimercapto-1-propanesulfonic acid, sodium salt is most potent and 2,3-dimercapto-1-propanol appears to be the least potent. The usefulness of all these dimercapto compounds would be enhanced by a careful study of their metabolism and biotransformation. These dimercapto compounds are in a great many respects orphan drugs.

A 29 yr old man was found unresponsive a few min after self injecting undetermined amounts of potassium cyanide & sodium arsenite iv in a suicide attempt. Treatment with the Lilly Cyanide Antidote kit rapidly resolved the initial coma, despite a whole blood cyanide level of 4.4 ug/ml. A 12 hr urine arsenic collection begun on admission showed 10,065 ug arsenic/12 hr. The patient received im BAL initially, which was followed by two 10-day courses of oral D-penicillamine. Complications included upper gi tract bleeding requiring transfusion, transient elevations of liver function tests, self limited complaints of decreased vision with conjunctival hyperemia & photophobia, & an abscess at the injection site. Although specific antidote therapy completely resolved the cyanide toxicity, early & prolonged arsenic chelation did not prevent a mild sensory peripheral neuropathy from developing with onset about 17 days after self injection.|Accumulation of heme oxygenase mRNA is strongly stimulated by treatment of cultured human skin fibroblasts with uv radiation, hydrogen peroxide, or the sulfhydryl reagent sodium arsenite. Since this will result in a transient reduction in the prooxidant state of cells, the phenomenon may represent an important inducible antioxidant defense mechanism. To examine the generality of the response, we have measured the accumulation of the specific mRNA in a variety of human & mammalian cell types after inducing treatments. Induction by sodium arsenite is observed in all addnl human cell types tested. This includes primary epidermal keratinocytes & lung & colon fibroblasts as well as established cell lines such as HeLa, TK6 lymphoblastoid, & transformed fetal keratinocytes. Strong induction of heme oxygenase mRNA is also observed following sodium arsenite treatment of cell lines of rat, hamster, mouse, monkey, & marsupial origin. The agents which lead to induction in cultured human skin fibroblasts fall into 2 categories: (a) those which are oxidants or can generate active intermediates (uv A radiation, hydrogen peroxide, menadione, & the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate); (b) agents which are known to interact with or modify cellular glutathione levels (buthionine sulfoximine, sodium arsenite, iodoacetamide, diamide, & cadmium chloride).|Very young children may be more susceptible. Study of 291 exposure incidents involving a single kind of ant bait in the form of a bottle containing 1/2 oz (15 mL) of sweetened 0.61% sodium arsenite soln permitted a poison control center to conclude that a dosage of <1 mg/kg can cause serious illness in a child & 2 mg/kg can cause death.|A cross-sectional study of workers at a factory where sodium arsenite was prepared found that workers with the highest arsenic exposure (mean air levels ranging from 0.384 to 1.034 mg As/m3 and estimated to avg 0.613 mg As/m3) tended to be grossly pigmented with hyperkeratinization of exposed skin and to have multiple warts ... .|For more Human Toxicity Excerpts (Complete) data for SODIUM ARSENITE (6 total), please visit the HSDB record page.

KML001

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

Cough. Headache. Laboured breathing. Sore throat. See Ingestion.

MAY BE ABSORBED! Redness. Pain.

Redness. Pain.

In 1975, 45.4 thousand kg were used in herbicides.|(1970-US): 454 thousand kg were used as an inhibitor of the corrosion caused in oil well piping, when oil wells are acidified with hydrochloric acid.

USEPA/OPP Pesticide Code 013603; Trade Names: Atlas "A"; Penite; Kill-All; Chem-Sen 56; Chem Pels C; Progalumnol Double.|POWDER 90%; SOLN 4, 6, 8 & 9.5%.|SPECIFICATION USUALLY REQUIRES A CONTENT OF AT LEAST 78% BY WEIGHT ARSENIOUS OXIDE.|Technical grade: 90-95% pure|For more Formulations/Preparations (Complete) data for SODIUM ARSENITE (6 total), please visit the HSDB record page.

Arsenenous acid, sodium salt (1:1): ACTIVE|COMMERCIAL PRODUCT KNOWN AS SODIUM ARSENITE WAS AT ONE TIME THOUGHT TO BE SODIUM-META-ARSENITE, SODIUM ARSENITE BUT IS NOW CONSIDERED TO BE A SOLID SOLN OF THE REACTANTS RATHER THAN A DEFINITE CMPD.|DO NOT USE MILK FROM DIPPED ANIMALS FOR SEVERAL DAYS AFTER DIPPING OR WITHIN WK AFTER WORMING WITH IT. DO NOT SLAUGHTER ANIMALS WITHIN WK AFTER TREATMENT. WHEN USED AS HERBICIDE FOR AQUATIC PLANTS, POND WATER WILL KILL LIVESTOCK WHEN FISH ARE UNAFFECTED.|20 ppm and 24.6 ppm sodium arsenite applied to an unspecified soil type increased yield in potatoes.|ALKALI ARSENITES WERE USED EXTENSIVELY FOR DESTROYING POTATO STEMS. POTENTIAL RISKS TO BOTH HUMAN & ANIMAL POPULATION PROVED SO GREAT THAT THESE CMPD WERE WITHDRAWN FROM AGRICULTURAL USE ...

EPA Method PMD-AS. Determination of Sodium Arsenite in Aqueous Formulations by Titration. Detection limit not specified.

Agrochemicals -> Fungicides, Insecticides|Health Hazards -> Carcinogens, Teratogens|HERBICIDES