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EGS

EGS structure

CAS No:
70539-42-3
Formula:
C18H20N2O12
Chemical Name:
EGS
Synonyms:
EGS;HI-EFF-2B;LAC-4R-886;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS);ETHYLENE GLYCOL BIS-(SUCCINIC ACID*N-HYD ROXYSUCCINI;ETHYLENE GLYCOL DISUCCINATE DI(N-SUCCINIMIDYL) ESTER
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

EGS Basic Attributes

Molecular Weight：

456.36

Exact Mass：

456.10200

NSC Number：

340009

HScode：

29280000

Characteristics

PSA：

180

XLogP3：

-2.3

Density：

1.52g/cm3

Boiling Point：

603.4ºC at 760 mmHg

Flash Point：

318.7ºC

Refractive Index：

1.56

Water Solubility：

acetic acid: water (1:1): ≤50mg/mL

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)|Analogs of those substrates or compounds which bind naturally at the active sites of proteins, enzymes, antibodies, steroids, or physiological receptors. These analogs form a stable covalent bond at the binding site, thereby acting as inhibitors of the proteins or steroids. (See all compounds classified as Affinity Labels.)

MeSH Entry Terms：

EGBSS

EGS Use and Manufacturing

bromoacetate amine and sulfhydryl reactive homobifunctional cross-linking reagent

Computed Properties

Molecular Weight:456.4
XLogP3:-2.3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:15
Exact Mass:456.10162408
Monoisotopic Mass:456.10162408
Topological Polar Surface Area:180
Heavy Atom Count:32
Complexity:736
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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high quality C18H20N2O12 99% transparent liquid KANBEI

CAS No.: 70539-42-3

Grade: Industrial Grade

Content: 99%

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