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Cimetidine hydrochloride

Cimetidine hydrochloride structure

CAS No:
70059-30-2
Formula:
C10H16N6S.ClH
Chemical Name:
Cimetidine hydrochloride
Synonyms:
Guanidine,N-cyano-N′-methyl-N′′-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]-,hydrochloride (1:1);Guanidine,N-cyano-N′-methyl-N′′-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-,monohydrochloride;Cimetidine hydrochloride;Cimetex;Biomag;Brumetidina;Notul;Tagamet Liquid;Tagamet Injection;Aciloc;98830-02-5
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

White or almost white, crystalline powder

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

Cimetidine hydrochloride Basic Attributes

Molecular Weight：

288.8

Exact Mass：

288.09200

EC Number：

274-297-2

UNII：

WF10491673

HScode：

2933290090

Characteristics

PSA：

114.19000

XLogP3：

2.18118

Appearance：

Type of white or white crystalline powder

Boiling Point：

488ºC at 760 mmHg

Flash Point：

248.9ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

MF0035100

Precautionary statement(s)：

P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Danger|H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)|Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

MeSH Entry Terms：

Altramet

Cimetidine hydrochloride Use and Manufacturing

Uses

Antagonist (to histamine H2receptors).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:288.80
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:288.0923934
Monoisotopic Mass:288.0923934
Topological Polar Surface Area:114
Heavy Atom Count:18
Complexity:296
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes