Mecamylamine hydrochloride
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Mecamylamine hydrochloride
structure -
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CAS No:
826-39-1
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Formula:
C11H21N.ClH
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Chemical Name:
Mecamylamine hydrochloride
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Synonyms:
Bicyclo[2.2.1]heptan-2-amine,N,2,3,3-tetramethyl-,hydrochloride (1:1);2-Norbornanamine,N,2,3,3-tetramethyl-,hydrochloride;Bicyclo[2.2.1]heptan-2-amine,N,2,3,3-tetramethyl-,hydrochloride;Mecamylamine hydrochloride;N,2,3,3-Tetramethyl-2-norbornanamine hydrochloride;Inversine;Mevasin;Mecamylamine chloride;Mevasine;CPDD 0059
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].
Mecamylamine hydrochloride is a monoterpenoid.
Mecamylamine hydrochloride Basic Attributes
203.75
203.144073
212-555-8
4956DJR58O
757086
2921300090
Characteristics
12.03000
3.61350
white solid
243-246 °C (decomp)
189.3ºC at 760 mmHg
58.1ºC
ethanol: 122 mg/mL
Desiccate at RT
Safety Information
6.1
UN 2811 6.1/PG 3
3
22-36/37/38
36/37/39
RB6900000
Xn
Missing Phrase - N15.00950417-P305 + P351 + P338
H301-H315-H319-H335
|Danger|H301 (97.56%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Mecamylamine hydrochloride Use and Manufacturing
Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.[Cayman Chemical]
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:203.75
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:203.1440774
Monoisotopic Mass:203.1440774
Topological Polar Surface Area:12
Heavy Atom Count:13
Complexity:197
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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