 Home > Encyclopedia > 4-CHLORODIPHENYLMETHANE

4-CHLORODIPHENYLMETHANE

4-CHLORODIPHENYLMETHANE structure

CAS No:
831-81-2
Formula:
C13H11Cl
Chemical Name:
4-CHLORODIPHENYLMETHANE
Synonyms:
NSC 83166;4-chloroditan;p-chlorobenzylbenzene;4-Benzylchlorobenzene;4-CHLORODIPHENYLMETHANE;p-chlorodiphenylmethane;1-(benzyl)-4-chloro-benzene;(p-chlorophenyl)phenylmethane;(p-chlorophenyl)phenyl-methan;(4-chlorophenyl)phenylmethane
Categories:
Organic Chemistry > Heterocyclic Ring

Request for Quotation

Description

Light yellow liquid

4-CHLORODIPHENYLMETHANE Basic Attributes

Molecular Weight：

202.681

Exact Mass：

202.05500

UNII：

DF8MF37RDF

NSC Number：

83166

DSSTox ID：

DTXSID1073238

HScode：

2903999090

Characteristics

PSA：

XLogP3：

4.9

Density：

1.1247 @ 20 DEG C/20 DEG C

Melting Point：

7.5 DEG C

Boiling Point：

298 DEG C @ 742 MM HG

Flash Point：

122ºC

Refractive Index：

1.583

Water Solubility：

INSOL IN WATER, SOL IN ACETONE

Safety Information

Marks：

Xi: Irritant;

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

4-CHLORODIPHENYLMETHANE Use and Manufacturing

General procedure: To a solution of Ph3PO (0.33 g, 1.2 mmol) in CH2Cl2 (1 mL), Tf2O (0.2 mL, 1.2 mmol) was added at 0 C and the solution was stirred for 15 min at room temperature. Then, arene (1 mmol) and benzyl alcohol (1 mmol) were added to the reaction mixture and the mixture was stirred for the appropriate time shown in Table 1 and Table 2. Upon completion of the reaction, the organic solvent was evaporated and the crude product was purified by column chromatography using n-hexane as eluent to give the diarylmethane. In the case of 4-nitrobenzyl alcohol, EtOAc/n-hexane (1:9) was used as the eluent.General procedure: A round-bottomed flask equipped with a condenser was charged with benzyl chloride (0.5 mmol), arylboronic acid (0.6 mmol), base (0.75 mmol), Pd(II) catalyst (3 mol%) and the mixture was stirred in 5 mL of solvent at 90 C for the required time. After completion, the reaction mixture was diluted with ether (10 mL), water (10 mL) and extracted with ether (3 ×10 mL). The combined extract was dried over MgSO4. After evaporation of the solvent under reduced pressure, the residue was purified by column chromatography to obtain the desired products.General procedure: A round-bottomed flask equipped with a condenser was charged with benzyl chloride (0.5 mmol), aryl boronic acid (0.6 mmol), base (1.0 mmol), PdCl2 (1.0 mol%) and the mixture was stirred in 5 mL of solvent at 90 C for the required time. After completion, the reaction mixture was diluted with ether (10 mL), water (10 mL) and extracted with ether (3 × 10 mL). The combined extract was dried over anhydrous Na2SO4. After evaporation of the solvent under reduced pressure, the residue was purified by column chromatography to obtain the desired products.

Computed Properties

Molecular Weight:202.68
XLogP3:4.9
Rotatable Bond Count:2
Exact Mass:202.0549280
Monoisotopic Mass:202.0549280
Heavy Atom Count:14
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-CHLORODIPHENYLMETHANE

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

High Quality 99% Purity of 4-Chlorodiphenylmethane CAS NO 831-81-2 ISO 9001:2005 REACH Verified Producer

CAS No.: 831-81-2

Grade: Industrial Grade

Content: 99%

Inquiry
Changzhou Xuanming Pharmaceutical Techno Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Peptides,Chemicals,API,Additives

High Cost Performance 4-Chlorodiphenylmethane 831-81-2

CAS No.: 831-81-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry