Xanthothricin
-
Xanthothricin
structure -
-
CAS No:
84-82-2
-
Formula:
C7H7N5O2
-
Chemical Name:
Xanthothricin
-
Synonyms:
Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione,1,6-dimethyl-;Pyrimido[5,4-e]-as-triazine-5,7(1H,6H)-dione,1,6-dimethyl-;1,6-Dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione;Toxoflavine;Xanthothricin;1,5,6,7-Tetrahydro-1,6-dimethylpyrimidino[5,4-e]triazine-5,7-dione;Toxoflavin;Xanthotricin;NSC 67078;PKF 118-310;SID 4251194;K4394;PKF118-310
-
CAS No:
Description
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2].
Toxoflavin is a pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. It has a role as an antineoplastic agent, a toxin, a Wnt signalling inhibitor, an apoptosis inducer, a bacterial metabolite, an antibacterial agent and a virulence factor. It is a pyrimidotriazine and a carbonyl compound. It derives from a reumycin.
Characteristics
77.7
-0.7
1.65g/cm3
165 °C
276.7ºC at 760 mmHg
121.1ºC
1.76
LD50 in mice (mg/kg): 1.7 i.v.; 8.4 orally (Machlowitz)
Xanthothricin Use and Manufacturing
Toxoflavin is a distinctive yellow pigment produced by some species of Pseudomonas and Streptomyces. Toxoflavin is one of two toxins produced when a fermented coconut drink, Tempe bonkrek, is contaminated with P. cocovenenans. Toxoflavin (PKF 118-310) is a potent antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.