Coenzyme A
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Coenzyme A
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CAS No:
85-61-0
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Formula:
C21H36N7O16P3S
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Chemical Name:
Coenzyme A
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Synonyms:
Coenzyme A;CoA;CoA-SH;Reduced CoA;Thiol-CoA;Adenosine 5′-(trihydrogen diphosphate),3′-(dihydrogen phosphate),P′-[3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester,(R)-;D-Coenzyme A;Coenzyme ASH;Aluzime;Coalip;Lucina;Adenosine 5′-(trihydrogen diphosphate) 3′-(dihydrogen phosphate) P′-[(R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutyl] ester;153-46-8;4151-41-1;16541-21-2
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CAS No:
Description
Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes
Characteristics
348
-0.30230
Clear golden liquid. With a stench.
2.0±0.1 g/cm3
-5ºC
146 - 147
1.737
−20°C
Safety Information
3
24/25
Stable at room temperature in closed containers under normal storage and handling conditions.
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 91 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Coenzyme A Use and Manufacturing
This product is extracted from fresh yeast and consists of pantothenic acid, adenine, ribose, cysteamine and phosphoric acid. The process steps are as follows: freshly squeezed yeast [broken wall] clear solution [primary adsorption] resin adsorbent [eluted] primary eluate [secondary adsorption] activated carbon adsorbent [eluted] secondary eluate [concentrated] concentrate [Reduction] reducing solution [complexation] complex [purification] purification solution [concentration] concentrated solution [precipitation] sediment [dry] Coenzyme A
Biochemical research; clinically used for the treatment of leukopenia, primary thrombocytopenic purpura, and functional hypothermia.
Coenzyme A: ACTIVE
Cosmetics -> Emollient; Solvent
Computed Properties
Molecular Weight:767.5
XLogP3:-5.8
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:21
Rotatable Bond Count:18
Exact Mass:767.11521025
Monoisotopic Mass:767.11521025
Topological Polar Surface Area:348
Heavy Atom Count:48
Complexity:1270
Undefined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Participate in body metabolism, supply energy, improve microcirculation, promote cell function recovery, activate organ function, and enhance immunity
Registered Holders
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Ma'anshan Fengyuan Pharmaceutical Co., Ltd.
Active
China
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Wuzhi Weierkang Biochemical Pharmaceutical Co., Ltd.
Active
China
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Sinopharm Ronshyn Pharmaceutical Co., Ltd.
Active
China
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