Cyclovirobuxine
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Cyclovirobuxine
structure -
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CAS No:
860-79-7
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Formula:
C26H46N2O
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Chemical Name:
Cyclovirobuxine
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Synonyms:
9,19-Cyclopregnan-16-ol,4,4,14-trimethyl-3,20-bis(methylamino)-,(3β,5α,16α,20S)-;9,19-Cyclo-5α,9β-pregnan-16α-ol,4,4,14-trimethyl-3β,20α-bis(methylamino)-;1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene,9,19-cyclopregnan-16-ol deriv.;(3β,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol;Cyclovirobuxine;Cyclovirobuxine D;Bebuxine;Cyclovirobuxin D;NSC 91722;Cyclovirobuxinum D;(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol;CVB-D;1354-65-0
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CAS No:
Description
Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. Cyclovirobuxine D induces autophagy and attenuates the phosphorylation of Akt and mTOR[1]. Cyclovirobuxine D inhibits cell proliferation of gastric cancer cells through suppression of cell cycle progression and inducement of mitochondria-mediated apoptosis[2]. Cyclovirobuxine D is beneficial for heart failure induced by myocardial infarction[3].
Characteristics
44.29000
4.86
1.1±0.1 g/cm3
220-221 °C (decomp) @ Solvent: Acetone
495.7±10.0 °C at 760 mmHg
34.1±9.6 °C
1.551
LD50 oral in mouse: 293mg/kg
Safety Information
24/25
|Danger|H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:402.7
XLogP3:5.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:402.361014095
Monoisotopic Mass:402.361014095
Topological Polar Surface Area:44.3
Heavy Atom Count:29
Complexity:692
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific pharmacological information is provided
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