Product
Supplier
Encyclopedia
Inquiry
Home > Encyclopedia > Diethylcarbamoyl chloride

Diethylcarbamoyl chloride

Diethylcarbamoyl chloride structure

Diethylcarbamoyl chloride 

structure
  • CAS No:

    88-10-8

  • Formula:

    C5H10ClNO

  • Chemical Name:

    Diethylcarbamoyl chloride

  • Synonyms:

    Carbamic chloride,N,N-diethyl-;Carbamoyl chloride,diethyl-;Carbamic chloride,diethyl-;N,N-Diethylcarbamic chloride;Diethylcarbamoyl chloride;N,N-Diethylcarbamoyl chloride;Diethylcarbamyl chloride;N,N-Diethylchloroformamide;(Diethylamino)carbonyl chloride;NSC 223067;N-(Chlorocarbonyl)diethylamine

  • Categories:

    Pharmaceutical Intermediates  >  Bulk Drug Intermediates

Description

clear yellow to brownish liquid

Diethylcarbamoyl chloride Basic Attributes

135.592

135.59

201-798-5

5RIV1U6H5W

512306|223067

1993

DTXSID0052598

Liquid

2903199000

Characteristics

20.31000

1.30

Clear to slightly greyish liquid

1.0712 g/cm3 @ Temp: 20 °C

-32 °C

186 °C

75.0±0.0 °C

1.446

HYDROLYSIS

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

4.1 (Air= 1)

Decomp in hot water or hot alcohol.

Safety Information

II

8

UN 3265 8/PG 3

1

R20/22;R36/37/38;R40

S26-S36/37

FD4025000

Xn:Harmful;

Stable under normal temperatures and pressures.

P261-P281-P305 + P351 + P338

H302-H315-H319-H332-H335-H351

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

REACTS WITH WATER OR STEAM TO PRODUCE TOXIC & CORROSIVE FUMES.

Flammable - 2nd degree, Reactive - 2nd degree

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 141 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures.|W - No water: Materials that react violently or explosively with water.

Toxicity

LD50 Mouse ip 750 mg/kg

Drug Information

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/

STUDY OF PERSONS EXPOSED TO DIETHYLCARBAMOYL CHLORIDE & DIMETHYLCARBOMYL CHLORIDE FOR 4-10 YR SHOWED A STATISTICALLY INSIGNIFICANT NUMBER OF CHROMOSOME ABERRATIONS WHEN COMPARED TO UNEXPOSED CONTROL GROUPS.

diethylcarbamoyl chloride

Diethylcarbamoyl chloride Use and Manufacturing

Methods of Manufacturing

Diethylamine + phosgene (phosgenation)

Carbamic chloride, N,N-diethyl-: ACTIVE

DETERMINATION OF DIETHYLCARBAMOYL CHLORIDE IN AIR USING GAS CHROMATOGRAPHY WITH A FLAME IONIZATION DETECTOR.

Fire Hazards -> Flammable - 2nd degree, Reactive - 2nd degree

Computed Properties

Molecular Weight:135.59
XLogP3:1.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:135.0450916
Monoisotopic Mass:135.0450916
Topological Polar Surface Area:20.3
Heavy Atom Count:8
Complexity:80.5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Diethylcarbamoyl chloride

Scan the QR Code to Share

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.