1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, iodide (1:2)
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1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, iodide (1:2)
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CAS No:
870-62-2
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Formula:
C12H30N2.2I
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Chemical Name:
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, iodide (1:2)
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Synonyms:
1,6-Hexanediaminium,N1,N1,N1,N6,N6,N6-hexamethyl-,iodide (1:2);Ammonium,hexamethylenebis[trimethyl-,diiodide;Hexamethylenebis[trimethylammonium iodide];1,6-Hexanediaminium,N,N,N,N′,N′,N′-hexamethyl-,diiodide;Hexamethonium iodide;Hexathide;Hexamethonium diiodide;Hexamethylenebis[trimethylammonium] diiodide;N1,N1,N1,N6,N6,N6-Hexamethylhexane-1,6-diaminium iodide
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CAS No:
Description
A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, iodide (1:2) Basic Attributes
456.19
456.05000
212-797-4
G2753KSN40
Drug Information
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery. (See all compounds classified as Ganglionic Blockers.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)
Bitartrate, Hexamethonium
Computed Properties
Molecular Weight:456.19
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:456.04984
Monoisotopic Mass:456.04984
Heavy Atom Count:16
Complexity:121
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, iodide (1:2)
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