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3-Hydroxypicolinic acid

3-Hydroxypicolinic acid structure

CAS No:
874-24-8
Formula:
C6H5NO3
Chemical Name:
3-Hydroxypicolinic acid
Synonyms:
2-Pyridinecarboxylic acid,3-hydroxy-;Picolinic acid,3-hydroxy-;3-Hydroxy-2-pyridinecarboxylic acid;3-Hydroxypicolinic acid;3-Hydroxy-2-carboxypyridine;2-Carboxy-3-hydroxypyridine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family.

Solid

3-hydroxypicolinic acid is a monohydroxypyridine that is picolinic acid in which the hydrogen at position 3 is replaced by a hydroxy group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of oligonucleotides. It has a role as a MALDI matrix material. It is a monohydroxypyridine and a monocarboxylic acid.

3-Hydroxypicolinic acid Basic Attributes

Molecular Weight：

139.11

Exact Mass：

139.11

BRN：

118954

EC Number：

212-859-0

DSSTox ID：

DTXSID80236320

HScode：

2933399090

Characteristics

PSA：

70.4

XLogP3：

1.3

Appearance：

White to almost white Fine Powder

Density：

1.5±0.1 g/cm3

Melting Point：

214-215 °C (decomp)

Boiling Point：

305ºC

Flash Point：

226.6±24.6 °C

Refractive Index：

1.626

Water Solubility：

soluble in water (0.25g in 10ml).

Storage Conditions：

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Packing level：

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-20/22

safety instructions：

26-28-36/37/39-36

Marks：

Xi,Xn

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 63 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3-hydroxy-2-pyridinecarboxylic acid

3-Hydroxypicolinic acid Use and Manufacturing

Synthetic Polymer MALDI Matrix Compounds

Computed Properties

Molecular Weight:139.11
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:139.026943022
Monoisotopic Mass:139.026943022
Topological Polar Surface Area:70.4
Heavy Atom Count:10
Complexity:137
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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3-Hydroxypicolinic acid

CAS No.: 874-24-8

Content: 99.00%

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