Nortriptyline hydrochloride
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Nortriptyline hydrochloride
structure -
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CAS No:
894-71-3
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Formula:
C19H21N.ClH
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Chemical Name:
Nortriptyline hydrochloride
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Synonyms:
1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-,hydrochloride (1:1);5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine,10,11-dihydro-N-methyl-,hydrochloride;1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-,hydrochloride;38489;Aventyl hydrochloride;Desmethylamitriptyline hydrochloride;10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine hydrochloride;5-[3-(Methylamino)propylidene]dibenzo[a,e]cyclohepta[1,5]diene hydrochloride;5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene hydrochloride;Noramitriptyline hydrochloride;Nortriptyline hydrochloride;Allegron;Nortrilen;Psychostyl;Acetexa;Noritren;Altilev;Pamelor;Vividyl;Norzepine;Sensival;Norfenazin;Nortryptilinium hydrochloride;8057-32-7;37025-22-2
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CAS No:
Description
Nortriptyline hydrochloride is a tricyclic antidepressant used to relieve the symptoms of depression.
Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.|Nortriptyline Hydrochloride is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.|A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
Nortriptyline hydrochloride Basic Attributes
299.84
299.144073
212-973-0
00FN6IH15D
169453|78248
DTXSID2045109
C704
2921490002
Characteristics
12
5.01930
white to off-white powder
213-215 °C
403.4°C at 760 mmHg
9℃
ethanol: 100 mg/mL
2-8°C
2.21X10-6 mm Hg at 25 deg C (est)
LD50 oral in rat: 405mg/kg
Safety Information
UN12303/PG2
3
22-36/38-23/25-11-39/23/24/25-23/24/25
22-36-45-24-16-7-36/37
HP0175000
Xn,T,F
Stable under recommended storage conditions. /Nortriptyline hydrochloride/
P301 + P312 + P330
H302
|Warning|H302 (95.35%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 44 companies from 5 notifications to the ECHA C&L Inventory.
Drug Information
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. (See all compounds classified as Adrenergic Uptake Inhibitors.)|Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)
Allegron
Nortriptyline hydrochloride Use and Manufacturing
Tricyclic antidepressant.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:299.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:299.1440774
Monoisotopic Mass:299.1440774
Topological Polar Surface Area:12
Heavy Atom Count:21
Complexity:307
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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