(4-Fluorophenyl)hydrazine hydrochloride
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(4-Fluorophenyl)hydrazine hydrochloride
structure -
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CAS No:
823-85-8
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Formula:
C6H7FN2.ClH
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Chemical Name:
(4-Fluorophenyl)hydrazine hydrochloride
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Synonyms:
Hydrazine,(4-fluorophenyl)-,hydrochloride (1:1);Hydrazine,(p-fluorophenyl)-,monohydrochloride;Hydrazine,(4-fluorophenyl)-,monohydrochloride;Hydrazine,(p-fluorophenyl)-,hydrochloride;(p-Fluorophenyl)hydrazine hydrochloride;(4-Fluorophenyl)hydrazine hydrochloride;1-(4-Fluorophenyl)hydrazine hydrochloride;(4-Fluorophenyl)hydrazine monohydrochloride
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CAS No:
(4-Fluorophenyl)hydrazine hydrochloride Basic Attributes
162.59
162.036011
3627721
212-521-2
75638
29280090
Characteristics
38
2.68660
White to brownish Powder
200 °C (decomp)
226.7ºC at 760 mmHg
90.9ºC
H2O: soluble
2-8°C
Safety Information
I; II; III
IRRITANT
2811
3
36/37/38-43-40-20/21/22
26-36-36/37/39-22
Xi,Xn
Irritant
Stable under normal temperatures and pressures.
P261-P305 + P351 + P338
H315-H319-H335
|Danger|H301 (37.8%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P311, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 82 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
(4-Fluorophenyl)hydrazine hydrochloride Use and Manufacturing
General procedure: A solution of 4-chloroaniline (127.6 g, 1 mol) in concentrated hydrochloric acid (293 mL) was stirred for 2 h at room temperature. To a solution of sodium nitrite (72.5 g, 1.05 mol) in water (145 mL) was added dropwise below 5 °C. After stirring 1 h, filtrate was separated by filtration, to which a solution of NaHSOGeneral procedure: CuBr (36 mg, 0.25 mmol, 2.5 mol percent), L3 (110 mg, 0.4 mmol, 4 mol percent), H2O (0.5 mL), and K3PO4 (254 mg, 1.2 mmol) were mixedin a 15 mL screw cap test tube. After STAC (110 mg, 0.3 mmol, 3 mol percent) and aryl bromide (10 mmol) were added, the resulting mixture was stirred at 80-110° C (bath temperature) for 10 min.Then K3PO4 (2.29 g, 10.8 mmol) and N2H4*H2O (1 g, 20 mmol) were added and argon (flow rate 5-7 mL/min) was bubbled through thereaction mixture for 5 min.28 The reaction mixture was stirred ina closed test tube at 80-110° C (bath temperature) for 1-2 h until complete consumption of starting material was observed as monitoredby TLC (eluentehexane), then cooled to room temperatureand diluted with SH2Cl2 (50 mL). The resulting solutionwas filteredand washed with brine (225 mL). Aq HCl (37percent) was added to the CH2Cl2 solution dropwise until pH 3-4. The formed precipitate was filtered, washed with SH2Cl2 (15 mL) and dried atroom temperature. NMR spectra of certain synthesized aryl hydrazine hydrochlorides showed that they contained 1-5 mol percent of the corresponding aniline hydrochlorides as impurities (see Supplementary data). Analytical samples of aryl hydrazine hydrochlorides were purified via precipitation from methanol solution by adding 2-3 volumes of diethyl ether.(4) salt A mixture of 22. 4 g of 4-fluorophenylhydrazine was dissolved in 15.6 ml of 37percent hydrochloric acid and stirred at 65 ° C until the reaction solution was crystallized. The mixture was cooled to 20 ° C, filtered, and the filter cake was washed with acetone. That is 4-fluorophenylhydrazine hydrochloride finished product 24. 6g, content of 99. 1percent, the yield of 39. 3percent
Computed Properties
Molecular Weight:162.59
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:162.0360041
Monoisotopic Mass:162.0360041
Topological Polar Surface Area:38
Heavy Atom Count:10
Complexity:79.1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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(4-Fluorophenyl)hydrazine hydrochloride
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