Rottlerin
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Rottlerin
structure -
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CAS No:
82-08-6
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Formula:
C30H28O8
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Chemical Name:
Rottlerin
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Synonyms:
2-Propen-1-one,1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-,(2E)-;Rottlerin;Acetophenone,3′-[(8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2′,4′,6′-trihydroxy-5′-methyl-;2-Propen-1-one,1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-,(E)-;(2E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one;NSC 56346;NSC 94525;Mallotoxin;PKC-δ/PKC-θ inhibitor;1402-21-7
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CAS No:
Description
Rottlerin is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM.
Characteristics
145
8.66
Orange to brown Powder
1.4±0.1 g/cm3
212 °C
800.4±65.0 °C at 760 mmHg
266.0±27.8 °C
1.682
2-8°C
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