(IODOMETHYL)CYCLOHEXANE

Under a nitrogen atmosphere, To a solution of cyclohexane methanol (5.00 mL, 40.7 mmol) in CH 2 Cl 2 (101 mL) at 0 ° C., Imidazole (3.6 g, 52.9 mmol), PPh 3 (13.9 g, 52.9 mmol) and I 2 (13.4 g, 52.9 mmol) were added, And the mixture was stirred for 30 minutes.after that, CH 2 Cl 2 was added to the reaction solution.The organic layer was washed with waterWashed with water and aqueous sodium thiosulfate solution.The organic layer was dried over Na 2 SO 4 and then concentrated.The concentrate was then filtered through Celite.The filtrate was concentrated. The resulting crude material was purified by column chromatography (silica gel 80 g, pentane) to obtain colorless oily substance 23 (5.82 g, 64percent).

Molecular Weight:224.08
XLogP3:4.3
Rotatable Bond Count:1
Exact Mass:224.00620
Monoisotopic Mass:224.00620
Heavy Atom Count:8
Complexity:55.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes