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Colistin sodium methanesulfonate

Colistin sodium methanesulfonate structure

CAS No:
8068-28-8
Formula:
Unspecified
Chemical Name:
Colistin sodium methanesulfonate
Synonyms:
COLIMYCIN SODIUM METHANESULFONATE;COLISTIN METHANESULFONATE SODIUM SALT;COLISTIN SODIUM METHANESULFONATE;(METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT;POLYMYXIN E SODIUM METHANESULFONATE;colimycinm;colistinat;colistinmethanesulfonicacid,sodiumsalt
Categories:
Chemical Reagents > Organic Reagents

Description

White or almost white, hygroscopic powder.

ChEBI: A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative, it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

Two forms of colistins, colistin sulfate and colistin methanesulfonate sodium (Colistin sodium methanesulfonate)(CMS-Na), are commercially available. CMS-Na is administered intravenously, and CMS, the free base of CMS-Na consisting of CMS A and CMS B, is hydrolyzed in vivo to form active colistin A and colistin B6 . Colistin first became available for clinical use in 1959 and has been used worldwide for several decades[5].

Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO

Colistin sodium methanesulfonate Basic Attributes

Molecular Weight：

1749.82

Exact Mass：

1758.615845

EC Number：

232-516-9

TSCA：

TSCA listed

Color/Form：

white to faintly beige

HScode：

2941906000

Characteristics

PSA：

749

Appearance：

white to faintly beige

Melting Point：

>228°C (dec.)

Water Solubility：

Freely soluble in water

Storage Conditions：

2-8°C

Toxicity：

LD50 i.v. in mice: >550 mg/kg (Barnett)

PH：

6-8 (10mg/mL in H2O)

Critical Temperature & Pressure：

2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

RTECS Number：

GH1650000

Precautionary statement(s)：

P201, P202, P260, P263, P264, P270, P281, P308+P313, P405, P501

Hazard Statements：

H361

RIDADR：

3249

Colistin sodium methanesulfonate Use and Manufacturing

antibacterial

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.

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Content: 99.9%

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Latest News on Colistin sodium methanesulfonate

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Guide of Colistin sodium methanesulfonate

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Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
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