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Fluticasone propionate

Fluticasone propionate structure

CAS No:
80474-14-2
Formula:
C25H31F3O5S
Chemical Name:
Fluticasone propionate
Synonyms:
Androsta-1,4-diene-17-carbothioic acid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-,S-(fluoromethyl) ester,(6α,11β,16α,17α)-;Fluticasone propionate;Fluticasone 17-propionate;Flixotide;Flutide;Flutide N;Flixonase;Flovent Diskus;Flovent;Cutivate cream;Flonase;Flunase;Flutivate;Flixotide Disks;Flixotide Disk;Flixotide Inhaler;Zoflut;Atemur Mite;Cutivate;Flixonase Nasal Spray;Flonase Aq;CCI 18781;Cyclesonide;Fluticone;Axotide;Flovent Rotadisk;Rotadisk;F 9428
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.Target: Glucocorticoid ReceptorFluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis. It is also used to treat eosinophilic esophagitis. Fluticasone propionate is a synthetic trifluorinated glucocorticoid. It is highly lipophilic (logp octanol/water 3.69). In studies

Fluticasone propionate Basic Attributes

Molecular Weight：

500.57

Exact Mass：

500.57

EC Number：

1308068-626-2

DSSTox ID：

DTXSID8045511

HScode：

29372900

Characteristics

PSA：

105.97000

XLogP3：

3.73

Appearance：

white solid

Density：

1.3±0.1 g/cm3

Melting Point：

272-273 °C (decomp)

Boiling Point：

568.3±50.0 °C at 760 mmHg

Flash Point：

297.5±30.1 °C

Refractive Index：

1.556

Water Solubility：

DMSO: ≥10 mg/mL

Storage Conditions：

Store at RT

Toxicity：

LD50 oral in rat: > 2gm/kg

Specific rotation：

D +30° (c = 0.35)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

BV7980000

GHS Classification：

|Danger|H302 (26.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P285, P301+P312, P302+P352, P304+P341, P308+P313, P314, P321, P330, P333+P313, P342+P311, P363, P391, P405, and P501|Aggregated GHS information provided by 16 companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fluticasone propionate Use and Manufacturing

Methods of Manufacturing

Compound (I) is first reacted with N, N-dimethylthiochloroformamide, and then hydrolyzed to obtain the corresponding thiocarboxylic acid (II), and then reacted with -bromo-fluoromethane to obtain fluticasone propionate.

Uses

A high-affinity, selective glucocorticoid receptor agonist

Computed Properties

Molecular Weight:500.6
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:500.18442974
Monoisotopic Mass:500.18442974
Topological Polar Surface Area:106
Heavy Atom Count:34
Complexity:984
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is a highly effective glucocorticoid with local anti-inflammatory effects. After transdermal administration, the inhibitory effect on the HPA axis is very weak, so its therapeutic index is higher than most commonly used steroid preparations. Subcutaneous injection produces a strong systemic glucocorticoid effect, but the oral effect is weak, which may be due to metabolic inactivation. In vitro tests have shown that this drug has a strong affinity and stimulatory effect on the human glucocorticoid receptor. Fluticasone propionate has no expected pheromone effect and has no obvious effect on the central nervous system, peripheral nervous system, gastrointestinal tract, cardiovascular system, and respiratory system.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fluticasone Propionate Cream
Ingredients	The main ingredient of this product is fluticasone propionate; its chemical name is: (6α, 11β, 16α, 17α)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-androsta-1,4-diene-17-carboxylic acid thioate, S-fluoromethyl ester;
Indication	Not yet clear.

Salmeterol Fluticasone Inhalation Powder
Ingredients	This product is a compound preparation, its components are: salmeterol (in the form of xinafoate) and fluticasone propionate. Each bubble contains 50 micrograms of salmeterol and 100 micrograms of fluticasone propionate; each bubble contains 50 micrograms of salmeterol and 250 micrograms of fluticasone propionate.
Indication	1. Patients with reversible obstructive airway disease should avoid the use of selective and non-selective beta-blockers unless absolutely necessary. 2. Since the plasma concentrations achieved at inhaled doses are very low, clinically significant drug interactions are unlikely to occur. When using known strong CYP3A4 inhibitors (such as diconazole and ritonavir) at the same time, attention should be paid to the possibility of increased systemic exposure due to the use of fluticasone propionate.
Specifications	50ug/100ug/soak

Fluticasone propionate nasal spray
Ingredients	Fluticasone propionate nasal spray: The concentration of the liquid is 0.05%, which is equivalent to 50 micrograms of fluticasone propionate per spray. The excipients are: glucose, microcrystalline cellulose and sodium carboxymethyl cellulose, phenylethyl alcohol, benzalkonium chloride, Tween 80, dilute hydrochloric acid, and purified water. Salmeterol and fluticasone powder inhalation: salmeterol and fluticasone propionate.
Indication	1. Avoid using this product with ritonavir. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	120 sprays

See More Related Drugs

Registered Holders

STERLING SPA

United States
Active
GLAXOSMITHKLINE

United States
Active
HOVIONE FARMACIENCIA SA

Japan
Active

See More Registered Holders

Recommended Suppliers of Fluticasone propionate

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

C25H31F3O5S 99% Dideu

CAS No.: 80474-14-2

Grade: Pharmaceutical Grade

Content: 99%

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