5-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINEHYDROCHLORIDE

Dissolve 5-bromoisoquinoline (25 g, 120.2 mmol) with acetic acid (250 mL).Add 3eq NaBH4 (13.6 g, 359.5 mmol), react at room temperature, and monitor the reaction with LC-MS.Adjust pH~8 with saturated aqueous NaHCO3 solution, extract with ethyl acetate, collect and wash the organic phase, dry, remove the solvent and purify by column chromatography.5-Bromo-1, 2, 3, 4-tetrahydroisoquinoline (10 g, yield: 40percent).The A25-3 (590mg, 1.92mmol), saturated aqueous sodium carbonate solution (2.4 mL) and methanol (2.4 mL) added to the flask, followed by stirring at 60 1h, the methanol was removed spin, water was added to 15mL, extracted three times with ethyl acetate, the combined organic phase was washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, Rotary did a colorless oily compound (200mg, 49percent).General procedure: step 1:The non-lipid compound (see Table 1 for specific substances) and the 1, 2, 3, 4-tetrahydroisoquinoline compound (specificThe substance is shown in Table 1) added to the reaction vessel, Copper-containing compounds (see Table 1 for specific substances), Additives (see Table 1 for specific substances) and organic solvents (see Table 1 for specific substances) were added to the reaction vessel.Step 2: uniformly heat the reaction vessel (such as oil bath) to the temperature described in Table 1, The oxime compound and the 1, 2, 3, 4-tetrahydroisoquinoline compound are reacted in an organic solvent and continue for the time described in Table 1;The reaction atmosphere to be described can be reacted by selecting air.Of course, the amount of oxygen required is 15-30%.Step 3: Purification step.

Molecular Weight:212.09
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:210.99966
Monoisotopic Mass:210.99966
Topological Polar Surface Area:12
Heavy Atom Count:11
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes