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4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one structure

CAS No:
80841-78-7
Formula:
C5H5ClO3
Chemical Name:
4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
Synonyms:
1,3-Dioxol-2-one,4-(chloromethyl)-5-methyl-;4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one;4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole;(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl chloride;4-(Chloromethyl)-5-methyldioxol-2-one
Categories:
Pharmaceutical Intermediates > Cardiovascular Agents

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Description

4-Cloromethyl-5-methyl-1,3-dioxol-2-one is Pale Yellow Oil

4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one Basic Attributes

Molecular Weight：

148.54

Exact Mass：

148.54

EC Number：

1592732-453-0

HScode：

29329990

Characteristics

PSA：

35.5

XLogP3：

1.1

Density：

1.362±0.06 g/cm3(Predicted)

Boiling Point：

>90℃/2mm

Flash Point：

129 °C

Refractive Index：

1.4760-1.4820

Safety Information

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one Use and Manufacturing

Methods of Manufacturing

4725 g of dichloroethane was added to the DMDO that was stirred up.1012.5g N-chlorosuccinimideAnd 45g benzoyl peroxide, Reaction temperature 90°C, reaction time 5.5h, The crude product obtained DMDO-Cl 382.5g, a yield of 85.00percent;

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). 4-Chloromethyl-5-methyl-1,3-dioxol-2-one is also used in the preparation of prodrugs of ampicillin.

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CAS No.: 80841-78-7

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-Cloromethyl-5-methyl-1,3-dioxol-2-one KEK

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Guide of 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
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4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

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