Z-TYR-OBZL
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Z-TYR-OBZL
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CAS No:
5513-40-6
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Formula:
C24H23NO5
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Chemical Name:
Z-TYR-OBZL
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Synonyms:
Z-TYR-OBZL;Z-TYROSINE-OBZL;Z-L-TYROSINE-BENZYL ESTER;Cbz-L-Tyrosine benzyl ester;N-Cbz-L-Tyrosine benzyl ester;N-ALPHA-CARBOBENZOXY-L-TYROSINE-BENZYL ESTER;L-Tyrosine, N-[(phenylMethoxy)carbonyl]-, phenylMethyl ester;(S)-Benzyl 2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoate
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CAS No:
Z-TYR-OBZL Use and Manufacturing
L-tyrosine benzyl p-toluenesulfonate (500 g, 1.13 mol) was added to 1, 4-dioxane (2.5 L) and water (2.5 L), followed by sodium bicarbonate (285 g, 3.39). Mol).The ice water bath was cooled to 0-5 C, and Cbz-Cl (192 g, 1.13 mol) was added dropwise thereto.The temperature control does not exceed 5 C. After the addition was completed, the reaction was continued for 4 hours in an ice water bath.Water (5 L) and ethyl acetate (4 L) were added thereto, stirred, and separated.The organic phase was washed with saturated brine. The organic phase is dried over anhydrous sodium sulfate.Filtration and concentration gave compound 1 (435 g, 95% yield).
Computed Properties
Molecular Weight:405.4
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:405.15762283
Monoisotopic Mass:405.15762283
Topological Polar Surface Area:84.9
Heavy Atom Count:30
Complexity:520
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
