4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
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4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
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CAS No:
82632-77-7
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Formula:
C10H9ClN2S
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Chemical Name:
4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
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Synonyms:
CHEMBRDG-BB 3007469;4-(4-chlorophenyl)-5-methyl-2-thiazolamine;4-(4-Chlorophenyl)-5-Methylthiazol-2-aMine;4-(4-CHLOROPHENY)-5-METHYLTHIAZOL-2-YLAMINE;4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE;4-(4-CHLOROPHENYL)-5-METHYL-1,3-THIAZOL-2-AMINE;4-(4-chlorophenyl)-5-methyl-1,3-thiazol-2-amine(SALTDATA: FREE)
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CAS No:
Characteristics
67.2
3.3
1.3±0.1 g/cm3
144-145℃ (hexane ethyl acetate )
376.6°C at 760 mmHg
181.6±23.7 °C
1.650
Safety Information
22-37/38-41
26-39
Xi
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE Use and Manufacturing
General procedure: Thiourea (0.04 mol) and iodine (0.02 mol)were triturated and mixed with appropriate 4-substituted propiophenone (0.02 mol), the mixture was heated on a water bathat 70 °C with occasional stirring for 8 h. The solid product was triturated and mixed with ethyl ether to remove unreacted 4-substituted phenyl propiophenone, washed with aqueous thiosulphate (5 percent) to remove excess iodine and finally with water. The crude product was dissolved in hot water, filtered toremove impurity and 2-amino-4-(4'-substituted phenyl)-5-methyl-1, 3-thiazole (Scheme-II) was precipitated by additionof ammonia solution. The product was recrystallized from ethanol to give crystal of desired product [9].
Computed Properties
Molecular Weight:224.71
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:224.0174972
Monoisotopic Mass:224.0174972
Topological Polar Surface Area:67.2
Heavy Atom Count:14
Complexity:195
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
4-(4-CHLORO-PHENYL)-5-METHYL-THIAZOL-2-YLAMINE
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