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Droloxifene

Droloxifene structure

CAS No:
82413-20-5
Formula:
C26H29NO2
Chemical Name:
Droloxifene
Synonyms:
Phenol,3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-;Phenol,3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-,(E)-;Phenol,3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-;3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol;K 060;K 21.060E;3-Hydroxytamoxifen;K 060E;Droloxifene;E-Droloxifene;887501-03-3
Categories:
Active Pharmaceutical Ingredients > Antineoplastic Agents

Description

Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats [1][2][3].

Droloxifene Basic Attributes

Molecular Weight：

579.64

Exact Mass：

387.51

EC Number：

428-010-4

DSSTox ID：

DTXSID20274463

Characteristics

PSA：

164.83000

XLogP3：

4.45320

Appearance：

off-White to Pale-Beige Solid

Density：

1.092 g/cm3

Melting Point：

158-159 °C

Boiling Point：

526.6ºC at 760 mmHg

Refractive Index：

1.596

Storage Conditions：

Amber Vial, -20°C Freezer

Safety Information

GHS Classification：

|Danger|H317: May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P261, P272, P273, P280, P281, P302+P352, P308+P313, P321, P333+P313, P363, P391, P405, and P501

Droloxifene Use and Manufacturing

anti-estrogen, anti-hyperlipoproteinemic, reduces bone loss

Computed Properties

Molecular Weight:387.5
XLogP3:6.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:8
Exact Mass:387.219829168
Monoisotopic Mass:387.219829168
Topological Polar Surface Area:32.7
Heavy Atom Count:29
Complexity:501
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes