Trimetrexate glucuronate
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Trimetrexate glucuronate
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CAS No:
82952-64-5
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Formula:
C19H23N5O3.C6H10O7
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Chemical Name:
Trimetrexate glucuronate
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Synonyms:
D-Glucuronic acid,compd. with 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine (1:1);2,4-Quinazolinediamine,5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-,mono-D-glucuronate;Trimetrexate glucuronate;Neutrexin
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CAS No:
Description
Trimetrexate Glucuronate is a lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)
Safety Information
|Warning|H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:563.6
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:11
Exact Mass:563.22274227
Monoisotopic Mass:563.22274227
Topological Polar Surface Area:253
Heavy Atom Count:40
Complexity:648
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes