Zabicipril
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Zabicipril
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CAS No:
83059-56-7
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Formula:
C23H32N2O5
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Chemical Name:
Zabicipril
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Synonyms:
2-(N-(1-carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic acid 1-ethyl ester;S 9650;S-9650;S9650;zabicipril;UNII-475035SS4C;475035SS4C;Zabiciprilum;Zabicipril [INN]
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CAS No:
Description
Zabicipril is a non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its active form zabiciprilat. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Drug Information
2-(N-(1-carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic acid 1-ethyl ester
Computed Properties
Molecular Weight:416.5
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:416.23112213
Monoisotopic Mass:416.23112213
Topological Polar Surface Area:95.9
Heavy Atom Count:30
Complexity:611
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- fluorene
- tert butanol
- chlorpheniramini maleas
- cûs
- dimethyl sulfone
- ambeed