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Beclomethasone 17-monopropionate

Beclomethasone 17-monopropionate structure

CAS No:
5534-18-9
Formula:
C25H33ClO6
Chemical Name:
Beclomethasone 17-monopropionate
Synonyms:
Pregna-1,4-diene-3,20-dione,9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-,(11β,16β)-;Pregna-1,4-diene-3,20-dione,9-chloro-11β,17,21-trihydroxy-16β-methyl-,17-propionate;Pregna-1,4-diene-3,2O-dione,9-chloro-11β,17,21-trihydroxy-16β-methyl-,17-propionate;(11β,16β)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione;Beclomethasone 17-propionate;Beclomethasone 17-monopropionate

Description

Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3].

An ester of beclomethasone.

Beclomethasone 17-monopropionate Basic Attributes

Molecular Weight：

464.97900

Exact Mass：

464.98

EC Number：

226-888-1

UNII：

5BGA9FD55H

DSSTox ID：

DTXSID20203899

HScode：

29162090

Characteristics

PSA：

100.90000

XLogP3：

3.12590

Density：

1.3g/cm3

Melting Point：

100-102 °C

Boiling Point：

608.9ºC at 760mmHg

Flash Point：

322ºC

Refractive Index：

1.583

Storage Conditions：

-20ºC Freezer

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

17-BMP

Beclomethasone 17-monopropionate Use and Manufacturing

Active metabolite of Beclomethasone Dipropionate (BDP).

Computed Properties

Molecular Weight:465.0
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:464.1965665
Monoisotopic Mass:464.1965665
Topological Polar Surface Area:101
Heavy Atom Count:32
Complexity:925
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Learn More Other Chemicals

Beclomethasone 21-propionate

69224-79-9
Beclomethasone dipropionate

5534-09-8

Hot Searches: lithium carbonate formula; sodium sulfide compound; phosphate aluminium; lopamidol; bioglutide; magnesium phosphate formula

Guide of Beclomethasone 17-monopropionate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

Beclomethasone 17-monopropionate

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