2-(4-Methylpiperazin-1-yl)ethylamine
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2-(4-Methylpiperazin-1-yl)ethylamine
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CAS No:
934-98-5
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Formula:
C7H17N3
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Chemical Name:
2-(4-Methylpiperazin-1-yl)ethylamine
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Synonyms:
1-Piperazineethanamine,4-methyl-;Piperazine,1-(2-aminoethyl)-4-methyl-;4-Methyl-1-piperazineethanamine;1-(2-Aminoethyl)-4-methylpiperazine;1-Methyl-4-(2-aminoethyl)piperazine;2-(4-Methylpiperazin-1-yl)ethylamine;2-(4-Methyl-1-piperazinyl)ethanamine;2-(4-Methylpiperazino)ethanamine;4-(2-Aminoethyl)-1-methylpiperazine;2-(4-Methylpiperazin-1-yl)ethan-1-amine
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CAS No:
Description
Colorless liquid
2-(4-methyl-1-piperazinyl)ethanamine is a N-alkylpiperazine that is piperazine substituted by a methyl and a 2-aminoethyl group at the N atoms respectively. It has a role as a human metabolite.
2-(4-Methylpiperazin-1-yl)ethylamine Basic Attributes
143.23
143.23
213-296-3
Z79BOY08I2
DTXSID10239420
2933599090
Safety Information
R36/37/38
S26-S36/37/39
Xi: Irritant;
P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, P501
H314
|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 7 companies from 2 notifications to the ECHA C&L Inventory.
2-(4-Methylpiperazin-1-yl)ethylamine Use and Manufacturing
Step 5. To a stirred suspension of lithium aluminum hydride (3.3 g, 87 mmol) in dry THF (100 mL), cooled to 0 °C, a solution of 2-(4-methylpiperazin-l-yl)acetonitrile (11.2 g, 80.4 mmol) in dry THF (300 mL) was slowly added. The mixture was stirred at room temperature for 1 h. The mixture was cooled in an ice bath, then HTo an ice-cooled suspension of LiAlH4 (0.626 g, 16.50 mmol) in dry diethyl ether (18 mL) a solution of 23 (2.09 g, 15.00 mmol) in dry diethyl ether (27 mL) and THF (27 mL) was added dropwise. After 1 h, the ice-bath was removed and the reaction batch was stirred overnight at ambient temperature in an atmosphere of Ar. Subsequently the chemical reaction was quenched cautiously with 20percent aqueous NaOH and the mixture was stirred for 20 min. The solid was filtered off and the solvent was evaporated in vacuo giving 26 [0.150 g (7percent)] as a colourless oil. NMR data coincide with literature.[000703] Step 2: 4 g of the product obtained in step 1 (0.028 moles) was dissolved in a 1:1 mixture of Tetrahydrofuran:Diethylether and was added drop wise to a suspension of lithium aluminium hydride (3.2 g) in diethylether (20 mL) at 0°C. [000704] The reaction was stirred at room temperature for 24 hours, cooled to 0°C and 10 mL of NaOH 6N was added and mixture stirred for 20 minutes. The solid was removed by filtration and filtrate was evaporated to give the title compound (208) in 4.74percent yield.
Computed Properties
Molecular Weight:143.23
XLogP3:-0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:143.142247555
Monoisotopic Mass:143.142247555
Topological Polar Surface Area:32.5
Heavy Atom Count:10
Complexity:86.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(4-Methylpiperazin-1-yl)ethylamine
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