Styrene oxide

120.15

120.15

108582

202-476-7

TSCA listed

Clear colorless to slightly yellow

29109000

12.53000

1.75790

Styrene oxide is a clear colorless straw-colored liquid with a sweet pleasant odor. (NTP, 1992)

1.054 g/mL at 25 °C (lit.)

-37 °C (lit.)

194 °C (lit.)

74ºC

n20/D1.535(lit.)

3 g/L (20 ºC)

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should

<1 mm Hg ( 20 °C)

4.14 (vs air)

Non flammable

Explosive limits , vol% in air: 1.1-22

Sweet, pleasant

6.2×10-1mol/(m3Pa) at 25℃, HSDB (2015)

Insoluble in water.

Styrene oxide is incompatible with oxidizing agents. Also incompatible with acids and bases. Reacts with 4-(4'-nitrobenzyl)pyridine. Polymerizes exothermally and reacts vigorously with compounds possessing a labile hydrogen (e.g. alcohols and amines) in the presence of catalysts such as acids, bases and certain salts .

928 °F

Store below +30°C.

III

6.1

UN 2810

3

T

53-45-36/37-26

CZ9625000

T:Toxic;

Separated from acids, bases and food and feedstuffs. Ventilation along the floor.

Stability Unstable - polymerises readily with compounds possessing a labile hydrogen (such as acids and alcohols) in the presence of acids, bases or some salts. Combustible. Incompatible with strong oxidizing agents, acids, bases. Moisture sensitive.

P201-P261-P280-P305 + P351 + P338-P311

Toxic by ingestion and inhalation. Possible carcinogen.

Vapors may form explosive mixture with air. May polymerize on heating above 200C, under the influence of strong acids, strong bases; oxidizers, metal salts; such as aluminum chloride; catalysts for vinyl polymers. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

UN 2810 6.1/PG 3

Styrene oxide is combustible.

Styrene oxide is a mild to moderate skin irri-tant. Irritation from 500 mg was moderateon rabbit skin. The toxicity of this com-pound was low on test animals. Inhalationof 500 ppm in 4 hours was lethal to rats. Anin vivo and in vitro study in mice (Helmanet al. 1986) indicates acute dermal toxicity,causing sublethal cell injury.LD50 value, oral (mice): 1500 mg/kgStyrene oxide, however, may present aconsiderable health hazard as a mutagen,teratogen, and carcinogen. The reproduc-tive effects from inhalation observed in ratswere fetotoxicity, developmental abnormal-ities, and effects on fertility (Sikov et al.1986). There is sufficient evidence of its car-cinogenicity in animals, producing liver, gas-trointestinal tract, and skin tumors. Gavageexposure caused cancer in the forestomach ofboth sexes of rats and mice (McConnell andSwenberg 1994). Its cancer-causing effectson humans are unknown.No exposure limit has been set for thiscompound. Its toxic and irritant effects inhumans are quite low.