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DELAPRIL HCL

DELAPRIL HCL structure

CAS No:
83435-67-0
Formula:
C26H32N2O5.HCl
Chemical Name:
DELAPRIL HCL
Synonyms:
Dalapril Hcl;Defolder;DELAPRIL HCL;delapril hydrochloride;N-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-N-(indan-2-yl)gly cine hydrochloride;Adecut;Cupressin;CV 3317
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Delapril is an angiotensin-converting enzyme (ACE) inhibitor for the treatment of cardiovascular diseases[1].

Delapril is a new angiotensin-converting enzyme (ACE) inhibitor useful in the treatment of essential hypertension. Orally administered delapril is a prodrug which is de-esterified to its active diacid metabolite. In hypertensive patients delapril significantly decreased systolic blood pressure and ACE activity 24 hours after dosing without affecting endogeneous creatinine clearance.

ChEBI: Delapril hydrochloride is a peptide.

DELAPRIL HCL Basic Attributes

Molecular Weight：

Exact Mass：

488.207794

Color/Form：

White to off-white

Characteristics

PSA：

95.9

XLogP3：

3.80250

Appearance：

White crystalline powder

Melting Point：

166-170℃

Boiling Point：

659.7°C at 760 mmHg

Flash Point：

352.7ºC

Specific rotation：

D22 +18.5° (c = 1 in methanol)

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

hazard class code：

6.1

RTECS Number：

MB9668000

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

DELAPRIL HCL Use and Manufacturing

Antihypertensive; enzyme inhibitor (angiotensinconverting).

Delapril Hydrochloride is an angiotensin-converting-enzyme inhibitor (ACE) used as an antihypertensive drug in some European and Asian countries, but not in America.