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Nitarsone

Nitarsone structure

Nitarsone 

structure
  • CAS No:

    98-72-6

  • Formula:

    C6H6AsNO5

  • Chemical Name:

    Nitarsone

  • Synonyms:

    Arsonic acid,As-(4-nitrophenyl)-;Benzenearsonic acid,p-nitro-;Arsonic acid,(4-nitrophenyl)-;As-(4-Nitrophenyl)arsonic acid;Nitarsone;p-Nitrobenzenearsonic acid;(4-Nitrophenyl)arsonic acid;4-Nitrobenzenearsonic acid;(p-Nitrophenyl)arsonic acid;Histostat 50;Hep-a-Stat;Histostat;Nitarson;NSC 5085;p-Nitrophenyl arsenic acid;8027-77-8

  • Categories:

    Analytical Chemistry  >  Analysis Reagents

Description

ChEBI: An organoarsonic acid where the organyl group is 4-nitrophenyl.


Solid


Nitarsone is an organoarsonic acid where the organyl group is 4-nitrophenyl. It has a role as an antiprotozoal drug and an agrochemical. It is a C-nitro compound and an organoarsonic acid. It derives from a phenylarsonic acid.|Nitarsone is an organoarsenic compound. It is used as an additive in poultry feed to improve weight gain and feed efficiency, while preventing blackhead disease. It is marketed as Histostat by Zoetis, a publicly traded subsidiary of Pfizer.

Nitarsone Basic Attributes

247.04

247.04

202-695-8

JP2EN8WORU

760413|5085

DTXSID9045007

2931900090

Characteristics

103.35000

Solid

>310 °C (decomp)

540.9ºC at 760mmHg

243.3ºC

Oral-rat LDL0: 100 mg/kg

Thermal decomposition of toxic nitrogen oxides and arsenide gases

Safety Information

6.1

UN34656.1/PG3

3

23/25-50/53

20/21-28-45-60-61

CY6125000

T,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

P261-P273-P301 + P310-P311-P501

H301 + H331-H410

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

highly toxic

Drug Information

4-nitrobenzenearsonic acid

Nitarsone Use and Manufacturing

Methods of Manufacturing

Obtained by diazotization and arsine of p-nitroaniline. Add p-nitroaniline to hydrochloric acid, stir for 2h, put ice cubes to cool to -5℃, add sodium nitrite solution within 15min, and stir for about 1h to obtain diazonium salt solution. Dissolve arsenic trioxide and sodium carbonate in water, cool to below 25 ℃, add copper sulfate solution, and then add the above diazonium salt solution, the reaction temperature is controlled below 25 ℃, which can generate p-nitrophenylarsinic acid.

Uses

vasodilator (coronary)

Computed Properties

Molecular Weight:247.04
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:246.946192
Monoisotopic Mass:246.946192
Topological Polar Surface Area:103
Heavy Atom Count:13
Complexity:236
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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