Methyl trithion

314.81200

314.81

X08H286BAN

231692

DTXSID3040275

LIGHT YELLOW TO AMBER LIQ|Liquid or powder

2931900090

110.96000

5.29070

1.39g/cm3

-18ºC

370.5ºC at 760mmHg

177.9ºC

1.616

1.63mg/L(20 ºC)

...NON-CORROSIVE TO MILD STEEL & MAY BE STORED INDEFINITELY IN UNLINED STEEL DRUMS.

MODERATE MERCAPTAN-LIKE ODOR

FP: ABOUT -18 °C /TECHNICAL GRADE/

II

6.1(a)

3018

24/25-50/53

28-36/37-45-60-61

T: Toxic;N: Dangerous for the environment;

MODERATELY STABLE TO HEAT; RESISTANT TO HYDROLYSIS BECAUSE OF LOW WATER SOLUBILITY

P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501

USE OF RUBBER GLOVES, GOGGLES, RESPIRATOR &...PROTECTIVE CLOTHING. /ORGANOPHOSPHORUS PESTICIDES/|WORKERS HANDLING AND APPLYING ORGANOPHOSPHORUS PESTICIDES ... MUST BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. ... /ORGANOPHOSPHORUS PESTICIDES/

ANY MATERIAL SPILLED ON SKIN SHOULD BE IMMEDIATELY REMOVED WITH SOAP & WATER. WHEN SPRAYING & DUSTING...CONTAMINATED CLOTHING SHOULD BE CHANGED FREQUENTLY. /ORGANOPHOSPHORUS PESTICIDES/|CONTAINERS ... SHOULD BE CLEANED WITH A SUSPENSION OF BLEACHING POWDER IN WATER OR WITH OTHER ALKALINE SOLN AFTER SOAKING FOR 24 HR AND THEN BE RINSED WITH HOT WATER. /ORGANOPHOSPHORUS PESTICIDES/|THE STRICT OBSERVANCE OF HYGIENE RULES- NO SMOKING AND NO FOOD INTAKE DURING WORK, THOROUGH WASHING WITH SOAP AFTER WORK, CHANGING PROTECTIVE CLOTHING BEFORE GOING HOME- IS OF THE UTMOST IMPORTANCE. /ORGANOPHOSPHORUS PESTICIDES/|THE PROTECTIVE CLOTHING SHOULD BE KEPT IN SEPARATE PLACES WHERE IT CANNOT BE CONTAMINATED WITH TOXIC CHEMICALS. IT SHOULD BE FORBIDDEN TO KEEP THIS CLOTHING IN LIVING QUARTERS. PROTECTIVE CLOTHING MUST BE WASHED AT LEAST ONCE A WEEK AND EACH TIME IT IS CONTAMINATED WITH PESTICIDES. BEFORE WASHING THE CLOTHING SHOULD BE SOAKED FOR SEVERAL HOURS IN A CALCIUM CARBONATE SOLUTION. /PESTICIDES/

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

MODERATE EYE IRRITANT.

.../EXPERIMENT INDICATES/ A MINOR DEGREE OF ANTAGONISM BETWEEN ALDRIN & TRITHION IN RATS. /TRITHION/

Methyl trithion's production and former(3) use as a general purpose insecticide used on fruits, vegetables, and forage(1) may have resulted in its direct release to the environment(SRC). Methyl trithion is not a registered pesticide product in the US(2).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10,000(SRC), determined from a log Kow of 4.82(2) and a regression-derived equation(3), indicates that methyl trithion is expected to be immobile in soil(SRC). Volatilization of methyl trithion from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.0X10-7 atm-cu m/mole(4), using a fragment constant estimation method(4). Methyl trithion is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.7X10-5 mm Hg(5), determined from a fragment constant method(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10,000(SRC), determined from a log Kow of 4.82(2) and a regression-derived equation(3), indicates that methyl trithion is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.0X10-7 atm-cu m/mole(4), developed using a fragment constant estimation method(4). Methyl trithion may be susceptible to biodegradation by analogy to carbophenothion(SRC) which degraded after 2 weeks to approximately 10% of the 10 ug/l added to raw river water samples exposed to sunlight and artificial fluorescent light(7). According to a classification scheme(5), an estimated BCF of 1000(SRC), from its log Kow of 4.82(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is very high.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), methyl trithion, which has an estimated vapor pressure of 2.7X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase methyl trithion is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hrs(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(3) determined using a structure estimation method(3). Particulate-phase methyl trithion may be removed from the air by wet and dry deposition(SRC).

The rate constant for the vapor-phase reaction of methyl trithion with photochemically-produced hydroxyl radicals has been estimated as 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 2 hours(SRC) at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1).

An estimated BCF of 1000 was calculated for methyl trithion(SRC), using a log Kow of 4.82(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high.

4.68e+04 L/kg|The Koc of methyl trithion is estimated as 10,000(SRC), using a log Kow of 4.82(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that methyl trithion is expected to be immobile in soil.

The Henry's Law constant for methyl trithion is estimated as 1.0X10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that methyl trithion is expected to be essentially nonvolatile from water surfaces(2). Methyl trithion's Henry's Law constant(1) indicates that volatilization from moist soil surfaces will not occur(SRC). Methyl trithion is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.7X10-5 mm Hg(3), determined from a fragment constant method(3).

SURFACE WATER: Chemical analysis in the surficial bed material in the Delaware river estuary found <10 ug/kg methyl trithion(1). 174 Water and 163 bed sediments, tested for pesticides at Pesticide Monitoring Network Stations, were found to contain no methyl trithion(2).

Occupational exposure to methyl trithion may have occurred through dermal contact with this compound at workplaces where methyl trithion was produced or used. (SRC)

4. 4= VERY TOXIC, PROBABLE ORAL LETHAL DOSE (HUMAN) IS 50-500 MG/KG, BETWEEN 1 TEASPOON & 1 OUNCE FOR 70 KG PERSON (150 LB).

OXIDATIVE METAB OF TRITHION.../IN/ FIELD-GROWING LETTUCE. ...PRINCIPAL ROUTE OF OXIDN INVOLVED THIOETHER OXIDN TO FORM THE SULFOXIDE & THEN THE SULFONE. ... FOLLOWED BY PHOSPHOROTHIONATE OXIDN TO FORM THE THIOLPHOSPHATE SULFONE. /TRITHION/

Basic Treatment: Establish a patent airway. Suction if necessary. Aggressive airway control may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Organophosphates and related compounds/|Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Administer atropine. Correct hypoxia before giving atropine ... . Administer pralidoxime chloride (2 PAM). USE UNDER DIRECT PHYSICIAN ORDERS ONLY ... . Treat seizures with adequate atropinization and correction of hypoxia. Rarely is diazepam necessary ... . For hypotension with signs of hypovolemia, administer fluid cautiously and consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Organophosphates and related compounds/|Airway protection. Insure that a clear airway exists. Intubate the patients and aspirate the secretions with a large-bore suction device if necessary. Administer oxygen by mechanically assisted pulmonary ventilation if respiration is depressed. Improve tissue oxygenation as much as possible before administering atropine, so as to minimize the risk of ventricular fibrillation. In severe poisonings, it may be necessary to support pulmonary ventilation mechanically for several days. /Organophosphate pesticides/|Atropine sulfate. Administer atropine sulfate intravenously, or intramuscularly if intravenous injection is not possible. Remember that atropine can be administered through an endotracheal tube if initial IV access if difficult to obtain. Depending on the severity of poisoning, doses of atropine ranging from very low to as high as 300 mg/day may be required, or even continuous infusion. The objective of atropine antidotal therapy is to antagonize the effects of excessive concentrations of acetylcholine at end-organs having muscarinic receptors. Atropine does not reactivate the cholinesterase enzyme or accelerate disposition of organophosphate. Recrudescence of poisoning may occur if tissue concentrations of organophosphate remain high when the effect of atropine wears off. Atropine is effective against muscarinic manifestations, but it is ineffective against nicotinic actions, specifically muscle weakness and twitching, and respiratory depression. Despite the limitations, atropine is often a life-saving agent in organophosphate poisonings. Favorable response to a test dose of atropine (1 mg in adults, 0.01 mg/kg in children under 12 years) can help differentiate poisoning by anticholinesterase agents from other conditions. However, lack of response, with no evidence of atropinization (atropine refractoriness) is typical of more severe poisonings. The adjunctive use of nebulized atropine has been reported to improve respiratory distress, decrease bronchial secretions, and increase oxygenation. /Organophosphate pesticides/|For more Antidote and Emergency Treatment (Complete) data for METHYL TRITHION (17 total), please visit the HSDB record page.

PARATHION & ITS RELATIVES ARE KNOWN TO INHIBIT ENZYME CHOLINESTERASE IN ALL PARTS OF BODY... /PARATHION/|MODERATE EYE IRRITANT.|SYMPTOMATOLOGY: 1. NAUSEA...VOMITING, ABDOMINAL CRAMPS, DIARRHEA, EXCESSIVE SALIVATION... 2. HEADACHE, GIDDINESS, VERTIGO & WEAKNESS. 3. RHINORRHEA & SENSATION OF TIGHTNESS IN CHEST ARE COMMON IN INHALATION EXPOSURE. 4. BLURRING OR DIMNESS OF VISION, MIOSIS... TEARING, CILIARY MUSCLE SPASM, LOSS OF ACCOMMODATION & OCULAR PAIN... MYDRIASIS...SOMETIMES SEEN...PROBABLY DUE TO SYMPATHO-ADRENAL DISCHARGE. 5. LOSS OF MUSCLE COORDINATION, SLURRING OF SPEECH, FASCICULATIONS & TWITCHING OF MUSCLES (PARTICULARLY OF TONGUE & EYELIDS), & GENERALIZED PROFOUND WEAKNESS. 6. MENTAL CONFUSION, DISORIENTATION & DROWSINESS. /PARATHION/|SYMPTOMATOLOGY: 7. DIFFICULTY IN BREATHING, EXCESSIVE SECRETION OF SALIVA & OF RESP TRACT MUCUS, ORONASAL FROTHING, CYANOSIS, PULMONARY RALES & RHONCHI & HYPERTENSION, (PRESUMABLY DUE TO ASPHYXIA). 8. RANDOM JERKY MOVEMENTS, INCONTINENCE, CONVULSIONS, & COMA. 9. DEATH PRIMARILY DUE TO RESP ARREST ARISING FROM FAILURE OF RESP CENTER, PARALYSIS OF RESP MUSCLES, INTENSE BRONCHOCONSTRICTION OR ALL THREE. /PARATHION/

FORMERLY AN INSECTICIDE & ACARICIDE, OF WHICH APPROXIMATELY 100% WAS USED ON COTTON (1973 EST)

USEPA/OPP PC Code 058101n; Trade Names: Methyl trithion, methyl carbophenothion, R 1492.|...INCL AN EC (480 G AI/L); DUSTS OF VARIOUS AI CONTENT.|EMULSIFIABLE CONCENTRATE (4E AND 8E), WETTABLE POWDER (25W), DUST GRANULES.

...INTRODUCED IN 1958 BY STAUFFER CHEM CO...|US PATENT 2,793,224.|...COMPATIBLE WITH OTHER COMMON PESTICIDES.|.../IT/ IS A NON-SYSTEMIC ACARICIDE SIMILAR IN RANGE OF ACTIVITY TO ITS HOMOLOGUE CARBOPHENOTHION BUT MORE EFFECTIVE AGAINST COTTON BOLL WEEVIL; GENERALLY USED @ 50-100 G AI/100 L.|For more General Manufacturing Information (Complete) data for METHYL TRITHION (7 total), please visit the HSDB record page.

THIN-LAYER CHROMATOGRAPHY: RAGAB MTH; BULL ENVIRON CONT TOXICOL 2: 285 (1967). GETZ ME, WHEELER HG; JAOAC 51: 1101 (1968). GAS-LIQ CHROMATOGRAPHY: BOWMAN MC, BEROZA M; JAOAC 50: 1228 (1967).|UV SPECTROPHOTOMETRIC METHOD, ISOOCTANE SOLVENT. MENN ET AL; ANALYTICAL METHODS FOR PESTICIDES, PLANT GROWTH REGULATORS, & FOOD ADDITIVES, (G ZWEIG, ED) II: 45, ACADEMIC, NY, (1964).|EPA-B Method PMD-TLC. Thin-Layer Chromatography Systems for Identification of Pesticides - System 2.

INSECTICIDES