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Sotalol hydrochloride

Sotalol hydrochloride structure

CAS No:
959-24-0
Formula:
C12H20N2O3S.ClH
Chemical Name:
Sotalol hydrochloride
Synonyms:
Methanesulfonamide,N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-,hydrochloride (1:1);Methanesulfonanilide,4′-[1-hydroxy-2-(isopropylamino)ethyl]-,monohydrochloride;Methanesulfonamide,N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-,monohydrochloride;4′-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride;4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide hydrochloride;N-Isopropyl-β-(4-methanesulfonamidophenyl)ethanolamine hydrochloride;Sotalol hydrochloride;MJ 1999;4′-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide monohydrochloride;Sotalex;Sotacor;DL-MJ 1999;(±)-Sotalol hydrochloride;dl-Sotalol hydrochloride;Betapace;Darob;Sotalol HCl;N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride;4201-00-7
Categories:
Organic Chemistry > Amides

Description

Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.Target: Adrenergic ReceptorSotalol is a non-selective competitive β-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels. Sotalol is a competitive beta adrenoceptor antagonist devoid of membrane-stabilizing activity and intrinsic sympathomimetic activity that has no preferential actions on beta 1 or beta

Sotalol hydrochloride is a hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias. It has a role as a beta-adrenergic antagonist and an anti-arrhythmia drug. It contains a sotalol(1+).|An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.

Sotalol hydrochloride Basic Attributes

Molecular Weight：

308.82

Exact Mass：

308.096130

EC Number：

213-496-0

NSC Number：

760358|337251

DSSTox ID：

DTXSID8021278

HScode：

2935009090

Characteristics

PSA：

86.8

XLogP3：

3.43620

Appearance：

white to off-white powder

Melting Point：

206.5-207 °C

Boiling Point：

443.3ºC at 760 mmHg

Flash Point：

221.9ºC

Water Solubility：

soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.H2O: 20 mg/mL

Storage Conditions：

Store at RT

Toxicity：

Oral-rat LD50: 3450 mg/kg; Oral-Mouse LD50: 2600 mg/kg

Flammability characteristics：

Thermal decomposition to remove toxic nitrogen oxides, sulfur oxides, hydrogen chloride fumes

Collision Cross Section：

166.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

PB0826000

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (95.77%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 72 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

MeSH Entry Terms：

Darob

Sotalol hydrochloride Use and Manufacturing

Uses

A potent -adrenergic receptor antagonist.A class III antiarrythmic.It has been shown to prolong action potential and increases the refractory period

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:308.83
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:308.0961414
Monoisotopic Mass:308.0961414
Topological Polar Surface Area:86.8
Heavy Atom Count:19
Complexity:330
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sotalol Hydrochloride
Specifications	API
Manufacturer	Changzhou Pharmaceutical Factory Co., Ltd.

Sotalol Hydrochloride
Manufacturer	Xi'an Li Bang Pharmaceutical Co., Ltd.

Sotalol Hydrochloride Tablets
Ingredients	The main ingredient is sotalol hydrochloride. Chemical name: (R,S) 4-(1-hydroxy-2-isopropylaminoethyl) methanesulfonic acid aniline hydrochloride. Molecular formula: C12H20N2O3SHCl. Molecular weight: 308.8
Indication	1. It has a synergistic effect when used with other class Ⅰa, Ⅱ, and Ⅲ antiarrhythmic drugs. 2. It can aggravate conduction disorders when used with calcium antagonists, further inhibit ventricular function, and lower blood pressure. 3. It can cause hypotension and severe bradycardia when used with catecholamines (such as reserpine and guanethidine). 4. There are reports of increased blood sugar, requiring increased insulin and hypoglycemic drugs.
Specifications	40mg
Manufacturer	Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

See More Related Drugs

Registered Holders

Cambrex Profarmaco Milano S.r.l.

Japan
Active
CAMBREX PROFARMACO MILANO SRL

Brazil
Active
Shandong Luoxin Pharmaceutical Group HENGXIN Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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Sotalol hydrochloride

CAS No.: 959-24-0

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Sotalol hydrochloride

CAS No.: 959-24-0

Grade: industrial Grade

Content: 98%

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