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Home > Encyclopedia > Cyproheptadine hydrochloride

Cyproheptadine hydrochloride

pharmaceutical raw materials
Cyproheptadine hydrochloride structure

Cyproheptadine hydrochloride 

structure
  • CAS No:

    969-33-5

  • Formula:

    C21H21N.ClH

  • Chemical Name:

    Cyproheptadine hydrochloride

  • Synonyms:

    Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-,hydrochloride (1:1);Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-,hydrochloride;Cyproheptadiene hydrochloride;Periactin hydrochloride;Cyproheptadine hydrochloride;Periactin syrup;Peritol;Periactinol;VUFB 3511;Nuran;Periactin;Cycloheptadine Hydrochloride;Ciplactin;Practin;Triactin;8057-33-8

  • Categories:

    Active Pharmaceutical Ingredients  >  Antiallergic Drugs

Description

Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors


Cyproheptadine hydrochloride (anhydrous) is the hydrochloride salt of cyproheptadine. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate. It contains a cyproheptadine.|A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

Cyproheptadine hydrochloride Basic Attributes

323.85900

323.14400

213-535-1

0S9323MCT0

759282|169911

DTXSID5042586|DTXSID70274175

2933399090

Characteristics

3.24000

5.43780

254-256.5 °C @ Solvent: Ethanol, Diethyl ether

440.1ºC at 760mmHg

194.5ºC

ethanol: soluble

Store at RT

LD50 orl-rat: 295 mg/kg DRUGAY 6,340,82

171.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

III

6.1(b)

UN 2811

3

R22; R36/37/38

S26; S36

TM7050000

Xn

P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

H301

|Danger|H301 (45.36%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 98 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (49.35%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P280, P281, P301+P310, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 77 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)|Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)|Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

Antergan

Cyproheptadine hydrochloride Use and Manufacturing

Uses

Antipruritic;5-HT antagonist

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:323.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:323.1440774
Monoisotopic Mass:323.1440774
Topological Polar Surface Area:3.2
Heavy Atom Count:23
Complexity:423
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product can compete with histamine released from tissues for the H25 receptors on effector cells, thereby preventing the onset of allergic reactions and relieving the spasmodic and congestive effects of histamine.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • OLON S.P.A.

    Italy Italy
    Active
  • Zhongnuo Kailin Pharmaceutical Development (Suzhou) Co., Ltd.

    China China
    Active
  • China CHINO PHARMA Ltd

    China China
    Active

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