 Home > Encyclopedia > Drotaverine hydrochloride

Drotaverine hydrochloride

Drotaverine hydrochloride structure

CAS No:
985-12-6
Formula:
C24H31NO4.ClH
Chemical Name:
Drotaverine hydrochloride
Synonyms:
Isoquinoline,1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-,hydrochloride (1:1);Isoquinoline,1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-,hydrochloride;Isoquinoline,1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-,hydrochloride;No-Spa hydrochloride;Drotaverinium chloride;Isodihydroperparine hydrochloride;Tetraspasmin-Lefa;Drotaverin hydrochloride;Drotaverine hydrochloride;No-Spa;NOSH-BRA;Drotin;1-(3,4-Diethoxy-benzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline hydrochloride;53908-09-1
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Request for Quotation

Description

Pale-Yellow Crystalline Solid

Drotaverine hydrochloride Basic Attributes

Molecular Weight：

433.97

Exact Mass：

433.201996

EC Number：

1308068-626-2

DSSTox ID：

DTXSID40243590

HScode：

2933990090

Characteristics

PSA：

48.95000

XLogP3：

6.05600

Density：

1.097 g/cm3

Melting Point：

211-212 °C

Boiling Point：

564ºC at 760 mmHg

Flash Point：

240.7ºC

Storage Conditions：

-20°C Freezer

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 72 companies from 6 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

dihydroisoperparine

Drotaverine hydrochloride Use and Manufacturing

A papaverine analog

Computed Properties

Molecular Weight:434.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:433.2019862
Monoisotopic Mass:433.2019862
Topological Polar Surface Area:49
Heavy Atom Count:30
Complexity:511
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Drotaverine inhibits phosphodiesterase, increases CAMP concentration, activates CAMP-dependent protein kinase, affects the phosphorylation of myosin light chain kinase (MLCK) and its affinity with the calcium ion-calmodulin complex, thereby leading to muscle relaxation; at the same time, it reduces the calcium ion concentration in the cytoplasm through the CAMP pathway, exhibiting a calcium ion antagonist effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Drotaverine Hydrochloride Injection
Ingredients	Main ingredient: Drotaverine hydrochloride. Chemical name: 1-(3,4-diethoxy-benzyl)-6,7-diethoxy-3,4-dihydroisoquinoline hydrochloride hemiethanol.
Indication	Phosphodiesterase inhibitors, such as papaverine, reduce the anti-Parkinsonian effect of levodopa. Rigidity and tremor may be exacerbated when drotaverine is used concomitantly with levodopa.
Specifications	2ml:40mg (calculated as C24H31NO4.HCl.1/2C2H5OH)
Manufacturer	Jiangsu Lianhuan Pharmaceutical Co., Ltd.

Drotaverine Hydrochloride Injection
Ingredients	Main ingredient: Drotaverine hydrochloride. Chemical name: 1-(3,4-diethoxy-benzyl)-6,7-diethoxy-3,4-dihydroisoquinoline hydrochloride hemiethanol.
Indication	Phosphodiesterase inhibitors, such as papaverine, reduce the anti-Parkinsonian effect of levodopa. Rigidity and tremor may be exacerbated when drotaverine is used concomitantly with levodopa.
Specifications	2 ml: 40 mg

Drotaverine Hydrochloride Injection
Specifications	2ml:40mg

See More Related Drugs

Registered Holders

Biobetta Pharmaceuticals (Shanghai) Co., Ltd.

China
Active
EuroAPI Shanghai Ltd.

China
Active
Jiangxi Yiyou Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Drotaverine hydrochloride

HNB Biotech Contact Supplier

CN
1 YR

Business licensed Certified factory

Manufactory Supplier of Ivermectin,Active pharmaceutical ingredients,Cosmetics material,Chemical intermediate,Nootropic,Food additive,Herb extract,Antibiotics,API,Virginiamycin,Copper Peptide,Potassium iodide,Minoxidil,Praziquantel,Fipronil,Topiramate,Bromhexine,Furazolidone,Nitrofurazone,Clotrimazole,Mebendazole,Fenbendazole,Amprolium,Enramycin,Sulfamethoxazole

Safe customs clearance high quality CAS 985-12-6 Drotaverine hydrochloride Safe customs clearance

CAS No.: 985-12-6

Grade: High Purity Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Drotaverine hydrochloride

CAS No.: 985-12-6

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale Drotaverine hydrochloride 99% high quality see COA KANBEI

CAS No.: 985-12-6

Grade: Industrial Grade

Content: 99%

Inquiry

Latest News on Drotaverine hydrochloride

Learn More Other Chemicals

4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)

67652-33-9
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)

681807-60-3
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE

1052525-88-8
2-Cyclopropylbenzenemethanamine hydrochloride Formula

118184-64-8
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula

464877-45-0
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula

36362-09-1
4,7-Dichloro-2-propylquinoline hydrochloride Structure

1204812-22-5
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure

1170377-12-4
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)

832710-56-2
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride

1171843-02-9

Hot Searches: raw steroid powder; methyl ethyl ketone prices; medetomidine for sale; gemtesa med; price of anhydrous ammonia today; 2876-22

Guide of Drotaverine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Drotaverine hydrochloride

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.