Gum tragacanth

840000

150.234750957

232-552-5

DTXSID2021369

Dull white, translucent plates or yellowish powder

29400000

Slightly soluble in water.

Both the flaked and powdered forms of tragacanth are stable. Tragacanth gels are liable to exhibit microbial contamination with enterobacterial species, and stock solutions should therefore contain suitable antimicrobial preservatives. In emulsions, glycerin or propylene glycol are used as preservatives; in gel formulations, tragacanth is usually preserved with either 0.1% w/v benzoic acid or sodium benzoate. A combination of 0.17% w/v methylparaben and 0.03% w/v propylparaben is also an effect

Odorless

Insipid, mucilaginous taste|Bland, slimy taste

Insol fraction swells to gel and consists of 60-70% bassorin|Sol fraction tragacanthin is complex mixt of polysaccharides with D-galacturonic acid, sugars, traces of starch, cellulose|Viscosity of mucilages is reduced by adding acid, alkali, and sodium chloride particularly if the mucilage is heated; max initial viscosity of solutions @ pH 8; max stable viscosity near pH 5|Acid reaction; 1 g requires 0.9 ml 0.1 N sodium hydroxide for neutralization to phenolphthalein|For more Other Experimental Properties (Complete) data for TRAGACANTH GUM (12 total), please visit the HSDB record page.

NONH for all modes of transport

2

22-24/25

XW7750000

Stable. Incompatible with strong oxidizing agents. High levels of dust in the air create the risk of explosion.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|Gum tragacanth used as a stabilizer in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.|Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

A MUTAGENIC EVALUATION OF TRAGACANTH GUM BY LITTON BIONETICS FOR FDA.[PB-245 455; MUTAGENIC EVALUATION OF COMPOUND FDA 71-12: GUM TRAGACANTH; LITTON BIONETICS, INCORPORATED, PREPARED FOR FDA (NOV 1972)]

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

A mild allergen. A skin and eye irritant.

PROLONGED APPLICATION OF AN AQ SOLN OF N-METHYL-N'-NITRO-N-NITROSOGUANIDINE TO MOUSE SKIN INDUCED SQUAMOUS CELL CARCINOMA. A SYNTHETIC ACID POLYSACCHARIDE PREPARED BY DEGRADATION & SULFATION OF TRAGACANTH GUM DECREASED THE RATE OF CARCINOGENESIS & SIZE OF CARCINOMA.|STUDY OF ACTION OF GUM TRAGACANTH ON POTASSIUM PERMEABILITY OF ASCITES TUMOR CELLS.

LD50 Rat oral 16,400 mg/kg|LD50 Mouse oral 10,000 mg/kg|LD50 Rabbit oral 7200 mg/kg|LD50 Hamster oral 8800 mg/kg

...from Astragalus gummifer Labill (white gavan) or other asiatic species of Astragalus, Leguminosae, found largely in Iran, also in Asia Minor and in Syria.|Southwestern Europe, Greece, Turkey...

Cathartics; Excipients|TRAGACANTH POWDER, GIVEN ORALLY IN AMT OF 3 G/DAY TO PATIENTS SUFFERING FROM DERMATITIS, HAD MARKEDLY ANTIALLERGENIC THERAPEUTIC VALUE.|ANTI-TUMORIGENIC MECHANISMS BY TRAGACANTH WAS INVESTIGATED. TRAGACANTH ACTED BY BECOMING ATTACHED TO THE CELLULAR MEMBRANE, THEREBY, BLOCKING MITOSIS. THIS RESULTED IN A DEGENERATION OF TUMOR CELLS.|DEMULCENT BASE FOR CUTANEOUS MEDICATION; SUSPENDING AGENT FOR INSOL POWDERS; EMULSIFYING AGENT FOR OILS ADMIN ORALLY|For more Therapeutic Uses (Complete) data for TRAGACANTH GUM (6 total), please visit the HSDB record page.

1(?). 1= PRACTICALLY NON-TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QT (2.2 LB) FOR 70 KG PERSON. /GUMS, VEGETABLE/

Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc. (See all compounds classified as Excipients.)

ASIDE FROM AN OCCASIONAL ALLERGIC REACTION, THESE DRUGS CAN BE INGESTED IN LARGE AMT, WITH LITTLE DANGER OR DISTRESS EXCEPT FOR DIARRHEA, FLATULENCE, & RARELY FECAL IMPACTION. /GUMS, VEGETABLE/|A 33-YR-OLD MALE PT WITH A HISTORY OF SNEEZING, RHINORRHEA, & ALLERGY TO COAL-TAR, DRUGS/ASPIRIN WAS GIVEN PYRIBENZAMINE PLACEBOS CONTAINING GUM TRAGACANTH. HE DEVELOPED ASTHMA. SCRATCH TESTS, SC INJECTION, & NEUTRALIZATION TESTS CONFIRMED THE ALLERGY TO GUM TRAGACANTH.|Mildly toxic by ingestion. A mild allergen. A skin and eye irritant.

Gum Tragacanth

Grades: USP; FCC; Number 1, 2, 3.

Gum tragacanth: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).|TRAGACANTH IS REGARDED AS BEING COMPOSED OF SOL PORTION CALLED TRAGACANTHIN CONSISTING OF GLUCURONIC ACID & ARABINOSE, & INSOL, BUT SWELLABLE, PORTION CALLED BASSORIN, WHICH APPEARS TO BE A COMPLEX OF POLYMETHOXYLATED ACIDS.|TRAGACANTH IS A COMPLEX POLYSACCHARIDE CONTAINING D-GALACTURONIC ACID, D-GALACTOSE, D-XYLOSE, & L-ARABINOSE, WITH ASSOCIATED CALCIUM, MAGNESIUM, POTASSIUM CATIONS...|/COMPONENTS OF TRAGACANTH/...BASSORIN COMPRISES 60-70%, SWELLS IN WATER BUT DOES NOT DISSOLVE. TRAGACANTHIN...IS WATER SOL & CONSISTS OF A RING CONTAINING 3 MOLECULES OF GLUCURONIC ACID & 1 MOLECULE OF ARABINOSE WITH A SIDE CHAIN OF 2 MOLECULES OF ARABINOSE. ...ALSO CONTAINS SMALL AMT OF CELLUOSE, PROTEIN, & STARCH.|...SWELLS IN COLD WATER TO...VISCOUS COLLOIDAL SOLN, PROBABLY MOST VISCOUS OF...PLANT GUMS. VISCOSITY IS MOST IMPORTANT FACTOR IN EVALUATING TRAGACANTH & IS REGARDED AS A MEASURE OF QUALITY & UNIFORMITY...AS WELL AS GUIDE TO...BEHAVIOR AS SUSPENDING AGENT, STABILIZER, OR EMULSIFIER.|For more General Manufacturing Information (Complete) data for TRAGACANTH GUM (14 total), please visit the HSDB record page.

AOAC method 912.03. Acidity (Volatile) of Tragacanth Drugs. Titrimetric method.

Food additives|Food Additives -> EMULSIFIER; STABILIZER; THICKENER; -> JECFA Functional Classes|Cosmetics -> Viscosity controlling

Food Additives -> EMULSIFIER; STABILIZER; THICKENER;