Polyethylene glycol sorbitan trioleate
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Polyethylene glycol sorbitan trioleate
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CAS No:
9005-70-3
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Chemical Name:
Polyethylene glycol sorbitan trioleate
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Synonyms:
Sorbitan,tri-(9Z)-9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs.;Sorbitan,trioleate,polyoxyethylene derivs.;Sorbitan,tri-9-octadecenoate,poly(oxy-1,2-ethanediyl) derivs.,(Z,Z,Z)-;TO 55;TO 65;Polysorbate 85;Tween 85;Poly(oxyethylene) sorbitan trioleate;Glycosperse TO 20;Sorbitan polyethoxy trioleate;Sorbimacrogol trioleate 300;Crill 12;Polyoxyethylene sorbitan trioleic acid ester;Emsorb 6903;Polyethylene glycol sorbitan trioleate;Sorbon T 85;Nikkol TO 30;Ethoxylated sorbitan trioleate;Montanox 85;Rheodol TW-O 320;Newcol 3-85;T-MAZ 85;Sorbax PTO 20;Rikemal O 852;Sorbitan trioleate polyoxyethylene ether;Crillet 45;Emsorb 6913;Witconol AL 69-66;Toximul SEE 340;Sinopol 3-85;Alkamuls T 85;Eumulgin STO 80;Aceporol 345T;Tween 85LM;Lonzest STO 20;Alkamuls T 85V;Pionin D 945T;Ecoteric T 85;Rheodol TW-O 320V;Agnique STO 20;Tego STO 85V;Disponil STO 20;Nikkol TO 30V;Alkamuls PSTO 20;T 85;Agnique STO 2095;Rheodol TW 0320V;Desmodur N 100-ethoxylated sorbitan trioleate copolymer;Montanox 85VG-DF;Newkalgen D 945T;Blaunon OT 320;TW 85;TO 30;1340-86-9;9015-60-5;51367-06-7;111389-05-0;866916-41-8;872017-39-5;1630262-72-4
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CAS No:
Polyethylene glycol sorbitan trioleate Basic Attributes
428.600006103516
355.01842948
500-019-9
DTXSID4049743
34021300
Characteristics
0.00000
viscous liquid
1.028 g/mL at 20 °C
>230 °F
0-6°C
<1 mm Hg ( 20 °C)
LD50 orally in Rabbit: > 36000 mg/kg
Safety Information
1
24/25
WG2934000
|Warning|H319 (11.24%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, and P501|Aggregated GHS information provided by 301 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Polyethylene glycol sorbitan trioleate Use and Manufacturing
After preheating 1 mol disk 80, put it into the reaction kettle, add a sodium hydroxide aqueous solution of catalyst amount under stirring, start stirring, and vacuum dehydration. After replacing the air in the kettle with nitrogen, the temperature was raised to 140°C and 22 mol of ethylene oxide was started. The reaction temperature was maintained at 180 to 190°C. After the ethylene oxide was passed, the evacuation was stopped. After cooling, the material liquid is poured into a neutralization kettle and neutralized with acetic acid to about acid value 2, then decolorized with an appropriate amount of hydrogen peroxide, and finally dehydrated to a moisture content of 3%, and the finished product is obtained by cooling and discharging the packaging.
Lonzest(R) STO-20 is a mid-range HLB, nonionic surfactant suggested for use in textile chemicals (lubricant, emulsifier), household products (o/w emulsifier) and cosmetic formulations (o/w emulsifier).
Sorbitan, tri-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
EPA Safer Chemical Functional Use Classes -> Surfactants|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Emulsifying; Surfactant
Computed Properties
Molecular Weight:355.4
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:355.01842948
Monoisotopic Mass:355.01842948
Topological Polar Surface Area:128
Heavy Atom Count:23
Complexity:534
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
(1) According to the requirements of the "Non-clinical Drug Research Management Standards" and the relevant guidelines for preclinical research of new drugs in the country, the product was injected into mice at a dose of 0.8 ml/mouse. No abnormal toxic reaction or death was observed within 48 hours after injection. The abnormal toxicity test results for mice were qualified. (2) According to the method requirements for the antihypertensive substance test in the appendix of the "Pharmacopoeia of the People's Republic of China", this product was tested for antihypertensive substances in cats, and the results met the antihypertensive substance requirements specified in the Pharmacopoeia. (3) According to the requirements of the "Non-clinical Drug Research Management Standards" and the relevant guidelines for preclinical research of new drugs in China, the product was injected intraperitoneally into healthy white Hautley guinea pigs, 0.5 ml per guinea pig, once every other day, for 3 consecutive times for sensitization. The results showed that the product had no effect on the activity, food intake, and drinking water of guinea pigs, and had no significant effect on the weight gain of guinea pigs. No abnormal reactions occurred during the test, and no guinea pigs died. The incidence rate and mortality rate of allergic reactions were both 0.4) According to the requirements of the "Non-clinical Drug Research Management Standards" and the relevant guidelines for preclinical research of new drugs in China, the product was injected intravenously into healthy clean-grade ICR mice at a dose of 100 ml/kg. After administration, no abnormal reactions were observed in male and female mice, and no animal deaths were caused. The maximum dosage for mice is greater than 100 ml/kg.
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Polyethylene glycol sorbitan trioleate
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