Chondroitin sulfate
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Chondroitin sulfate
structure -
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CAS No:
9007-28-7
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Formula:
H2O4S.xUnspecified
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Chemical Name:
Chondroitin sulfate
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Synonyms:
Chondroitin,hydrogen sulfate;Chondroitinsulfuric acids;Chondroitin sulfate;Chondroitinsulfuric acid;Chondroitin sulphate;Chondroitin polysulfate;Chonsurid;Cosamin DS;Uracyst S 400;Chondroitin Q;ChondroGuard;Mucosatum;Marine Cartilage 40S;Marine Chondroitin;SCP-NBC;9046-20-2;9062-29-7;11120-14-2;56480-79-6
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CAS No:
Description
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
Glucosamine is a popular nutritional supplement and natural component of cartilage that is frequently combined with chondroitin sulfate and used for osteoarthritis and nonspecific joint pain. Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.|Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.
Chondroitin sulfate Basic Attributes
463.363
479.058105
232-696-9
DTXSID8031021
M - Musculo-skeletal system
39139000
Characteristics
267
-4.28
White to Off-white; Powder
2.0±0.1 g/cm3
190-194ºC
1.686
soluble in water
Store at RT
Safety Information
24/25
P261, P271, P272, P280, P285, P302+P352, P304+P312, P304+P340, P304+P341, P312, P321, P333+P313, P342+P311, P363, P501
H317
|Danger|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P271, P272, P280, P285, P302+P352, P304+P312, P304+P340, P304+P341, P312, P321, P333+P313, P342+P311, P363, and P501|Aggregated GHS information provided by 11 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Toxicity
In controlled trials, glucosamine and its combination with chondroitin have not been linked to serum enzyme elevations or to instances of clinically apparent liver injury. In addition, cases of clinically apparent liver injury have not been reported from prospective trials. Recently, several cases reports and small series of clinically apprent liver injury attributed to glucosamine (with or without chondroitin) have been published, but the relationship of glucosamine itself as opposed to other herbals in the implicated products or to potential contaminants, remains unclear and several cases were considered only "possibly" related to glucosamine. The time to onset is usually 1 to 4 weeks after starting the preparation and the pattern of injury is typically hepatocellular or mixed. At least one instance of acute liver failure has been reported. Immunoallergic features (rash, fever, eosinophilia) can occur, but are usually not prominent. Most patients were reported to recover within 4 to 8 weeks of stopping. There have not been instances of rechallenge with glucosamine, and the purity and concentration of glucosamine in the products used have not been reported.
Drug Information
Primary osteoarthritis
Glucosamine is a popular nutritional supplement and natural component of cartilage that is frequently combined with chondroitin sulfate and used for osteoarthritis and nonspecific joint pain. Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.
Herbal and Dietary Supplements
Blutal
Chondroitin sulfate Use and Manufacturing
Chondroitin sulfate is described as a skin-conditioning agent, with possible anti-inflammatory properties. It can be found in such products as moisturizers and night skin care preparations. It is a derivative of natural mucopolysaccharides.
Chondroitin, hydrogen sulfate: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
Human Drugs -> EU pediatric investigation plans|Cosmetics -> Antistatic; Hair conditioning
Computed Properties
Molecular Weight:463.37
XLogP3:-4.8
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:6
Exact Mass:463.06319014
Monoisotopic Mass:463.06319014
Topological Polar Surface Area:267
Heavy Atom Count:30
Complexity:739
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
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