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Detomidine hydrochloride

Detomidine hydrochloride structure

CAS No:
90038-01-0
Formula:
C12H14N2.ClH
Chemical Name:
Detomidine hydrochloride
Synonyms:
1H-Imidazole,5-[(2,3-dimethylphenyl)methyl]-,hydrochloride (1:1);1H-Imidazole,4-[(2,3-dimethylphenyl)methyl]-,monohydrochloride;Detomidine hydrochloride;Domosedan;Dormosedan;MPV 253AII
Categories:
Biochemical Engineering > Inhibitors

Description

Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonistTarget: α2-adrenergic agonistDetomidine is an imidazole derivative and α2-adrenergic agonist, used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to veterinarians sold under the trade name Dormosedan. Currently, detomidine is only licenced for use in h

Detomidine hydrochloride Basic Attributes

Molecular Weight：

222.7139

Exact Mass：

222.092377

UNII：

95K4LKB6QE

DSSTox ID：

DTXSID7048661

HScode：

2933290090

Characteristics

PSA：

28.7

XLogP3：

3.41930

Melting Point：

160 °C

Boiling Point：

386.5°C at 760 mmHg

Flash Point：

200.6ºC

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

RTECS Number：

NI5160000

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301+H331 (33.33%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 3 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)|Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

MeSH Entry Terms：

detomidine

Detomidine hydrochloride Use and Manufacturing

Uses

Detomidine produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:222.71
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:222.0923762
Monoisotopic Mass:222.0923762
Topological Polar Surface Area:28.7
Heavy Atom Count:15
Complexity:181
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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