Dimethyl isosorbide

clear colorless to light yellow liquid

The isosorbide, 1, 2-dimethoxyethane, and heteropolyacid were charged into a stainless steel reaction kettle, the autoclave was sealed, The reaction was magnetically stirred at 150 ° C for 5 hours. Wherein the molar ratio of 1, 2-dimethoxyethane to isosorbide is 20: 1, heteropoly acidAnd the mass ratio of isosorbide was 0.2: 1. After the reactor was cooled to room temperature, the reaction solution was analyzed by gas chromatography. IsosorbideThe conversion and the yield of its methylated product were calculated in terms of mole percent (molpercent) according to gas chromatography internal standard method.Isosorbide, Methyl etherate and acid catalystAmberlyst-35 was put into a stainless steel reaction kettle, Closed reactor, 130 ° C magnetic stirring for 15 hours. among them, The molar ratio of methylating reagent and isosorbide was 50: 1, The mass ratio of catalyst Amberlyst-35 to isosorbide was 0.5: 1. After the reactor was cooled to room temperature, The reaction solution was analyzed by gas chromatography. The conversion of isosorbide and its methylated product yield were calculated by gas chromatography internal standard method, In mole percent.Isosorbide, Methyl etherate and acid catalystAmberlyst-35 was put into a stainless steel reaction kettle, Closed reactor, 130 ° C magnetic stirring for 15 hours. among them, The molar ratio of methylating reagent and isosorbide was 50: 1, The mass ratio of catalyst Amberlyst-35 to isosorbide was 0.5: 1. After the reactor was cooled to room temperature, The reaction solution was analyzed by gas chromatography. The conversion of isosorbide and its methylated product yield were calculated by gas chromatography internal standard method, In mole percent.Isosorbide, Methyl etherate and acid catalystAmberlyst-35 was put into a stainless steel reaction kettle, Closed reactor, 130 ° C magnetic stirring for 15 hours. among them, The molar ratio of methylating reagent and isosorbide was 50: 1, The mass ratio of catalyst Amberlyst-35 to isosorbide was 0.5: 1. After the reactor was cooled to room temperature, The reaction solution was analyzed by gas chromatography. The conversion of isosorbide and its methylated product yield were calculated by gas chromatography internal standard method, In mole percent.The isosorbide, dimethoxymethane, diethylene glycol dimethyl ether and phosphorus tungsten heteropoly acid into the reaction of stainless steel Kettle, closed reactor, magnetic stirring, at 100 ° C reaction. Among them, the molar ratio of dimethoxymethane and isosorbideIs 30: 1, the molar ratio of diethylene glycol dimethyl ether and isosorbide is 0.5: 1, the mass ratio of phosphotungstic acid to isosorbide is0.5: 1. After the reactor was cooled to room temperature, the reaction solution was analyzed by gas chromatography. Conversion of isosorbide and its methylated product. The yield was calculated according to the gas chromatography internal standard method and expressed in mole percent (ppm).The isosorbide, diglyme, and acidic catalyst silicotungstic acid were charged into a stainless steel reaction kettle, Sealed reactor, a certain temperature magnetic stirring reaction for 2 hours. Wherein the molar ratio of diethylene glycol dimethyl ether to isosorbide20: 1, and the mass ratio of silicotungsten heteropoly acid to isosorbide was 0.01: 1. The reactor was cooled to room temperature and gas was usedThe reaction solution was analyzed by phase chromatography. The conversion of isosorbide and its methylated product yield were calculated by gas chromatography internal standard method.

dimethyl isosorbide is a carrier, solvent, and viscosity controller. Its particular skin-penetrating ability opens the possibility of enhancing active substance efficacy in optical products. Its physical characteristics and solubility properties are superior to those of propylene glycol, glycerin, or ethyl alcohol.

Molecular Weight:174.19
XLogP3:-0.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:174.08920892
Monoisotopic Mass:174.08920892
Topological Polar Surface Area:36.9
Heavy Atom Count:12
Complexity:143
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes