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(RS)-Clopidogrel

(RS)-Clopidogrel structure

CAS No:
90055-48-4
Formula:
C16H16ClNO2S
Chemical Name:
(RS)-Clopidogrel
Synonyms:
Thieno[3,2-c]pyridine-5(4H)-acetic acid,α-(2-chlorophenyl)-6,7-dihydro-,methyl ester;(±)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate;(±)-Clopidogrel;(±)-Methyl α-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-α-(o-chlorophenyl)acetate;Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate;2-(2-Chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester;(RS)-Clopidogrel;(S,R)-Clopidogrel;(2-Chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester;120202-73-5;94188-84-8
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetic acid methyl ester is an alpha-amino acid ester.|Clopidogrel is an inhibitor of platelet aggregation that is used to decrease the risk of myocardial infarction and stroke in patients known to have atherosclerosis. Clopidogrel has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.

(RS)-Clopidogrel Basic Attributes

Molecular Weight：

321.822

Exact Mass：

321.82

Characteristics

PSA：

68.78000

XLogP3：

4.23

Density：

1.3±0.1 g/cm3

Boiling Point：

423.7±45.0 °C at 760 mmHg

Flash Point：

210.0±28.7 °C

Refractive Index：

1.617

Toxicity

Hepatotoxicity：

Clopidogrel is associated with serum enzyme elevations in 1% to 3% of patients during therapy. In several large clinical trials, elevations of serum ALT were no more frequent with clopidogrel as with placebo (or in comparator arms) and no instances of clinically apparent liver injury were reported. Since marketing and release, however, there have been more than a dozen published case reports of clinically apparent liver injury attributed to clopidogrel. The onset of symptoms was within 2 to 24 weeks (averaging 6 weeks) of starting, with fatigue and jaundice. Several patients had an accompanying fever but rash and eosinophilia were not common. The usual pattern of liver enzyme elevations was hepatocellular, but cases with mixed or cholestatic enzyme elevations have also been described (Case 1). Autoantibodies were rarely present. Most cases were self-limited with recovery within 1 to 2 months, but rare cases of acute liver failure or hepatic decompensation with death or need for liver transplantation have been described.

Drug Information

LiverTox Summary：

Clopidogrel is an inhibitor of platelet aggregation that is used to decrease the risk of myocardial infarction and stroke in patients known to have atherosclerosis. Clopidogrel has been linked to rare instances of idiosyncratic, clinically apparent acute liver injury.

Drug Classes：

Antithrombotic Agents

Computed Properties

Molecular Weight:321.8
XLogP3:3.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:321.0590276
Monoisotopic Mass:321.0590276
Topological Polar Surface Area:57.8
Heavy Atom Count:21
Complexity:381
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 90055-48-4

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