Zabiciprilat
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Zabiciprilat
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CAS No:
90103-92-7
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Formula:
C21H28N2O5
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Chemical Name:
Zabiciprilat
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Synonyms:
carboxy-1-phenyl-3-propylamino-2-propionyl-2-aza-2-bicyclo(2.2.2)octane-3-carboxylic acid;S 10211;S-10211;zabiciprilat;zabiciprilate;UNII-0A2D355316;0A2D355316;Zabiciprilatum
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CAS No:
Description
Zabiciprilat is a non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Drug Information
carboxy-1-phenyl-3-propylamino-2-propionyl-2-aza-2-bicyclo(2.2.2)octane-3-carboxylic acid
Computed Properties
Molecular Weight:388.5
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:388.19982200
Monoisotopic Mass:388.19982200
Topological Polar Surface Area:107
Heavy Atom Count:28
Complexity:581
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes