2-AMINO-5-BROMO-3-PIPERIDIN-1-YLPYRAZINE

Amine (1.58 mmoll) was added to 2-amino-3, 5-dibromopyrazine 2 (0.791 mmol) in DMSO or ethanol (0.5 ml) and the mixture was heated to 120° C. in a sealed tube. If the amine was in short supply, one equivalent of amine and one equivalent of iPrAmine (1.58 mmoll) was added to 2-amino-3, 5-dibromopyrazine 2 (0.791 mmol) in DMSO or ethanol (0.5 ml) and the mixture was heated to 120 C. in a sealed tube. If the amine was in short supply, one equivalent of amine and one equivalent of iPr2NEt were used. The reaction was allowed to proceed for 18 h. The solution was cooled, partitioned between methylene chloride and water (1:1, 200 ml) and the organic phase removed. The aqueous phase was extracted with methylene chloride (50 ml) and the combined organic layers were dried over Na2SO4 and concentrated giving the product 5. ; Prepared from 2-amino-3, 5-dibromopyrazine and piperidine according to general procedure 4 (method 2) providing the diaminopyrazine (199 mg, 97%) as a yellow solid; 1H NMR (500 MHz, CDCl3) delta 7.72 (s, 1H), 4.53 (s, 2H), 3.12-3.10 (t, J=5.3 Hz, 4H), 1.71-1.67 (m, 4H), 1.65-1.61 (m, 2H).

Molecular Weight:257.13
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:256.03236
Monoisotopic Mass:256.03236
Topological Polar Surface Area:55
Heavy Atom Count:14
Complexity:184
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes