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Benziodarone

Benziodarone structure

CAS No:
68-90-6
Formula:
C17H12I2O3
Chemical Name:
Benziodarone
Synonyms:
Methanone,(2-ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)-;Ketone,2-ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl;(2-Ethyl-3-benzofuranyl)(4-hydroxy-3,5-diiodophenyl)methanone;L 2329;Amplivix;Benziodarone;Cardivix;2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)benzofuran;2-Ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)-3-coumarone;2-Ethyl-3-(4-hydroxy-3,5-diiodobenzoyl)benzofuran;2-Ethyl-3-(4-hydroxy-3,5-diiodobenzoyl)coumarone;Dilafurane;Dila-Vasal;Algocor;2329 Labaz;Retrangor;Corofam;Coronal-Crinos;NSC 82133;(2-Ethyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Benziodarone is an aromatic ketone.|Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients.

Benziodarone Basic Attributes

Molecular Weight：

518.08

Exact Mass：

518.08

EC Number：

200-695-2

UNII：

75CL65GTYR

NSC Number：

82133

DSSTox ID：

DTXSID1046134

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

50.4

XLogP3：

5.14100

Density：

1.993g/cm3

Melting Point：

167 °C

Boiling Point：

518.2ºC at 760 mmHg

Flash Point：

267.2ºC

Refractive Index：

1.727

Water Solubility：

5.881mg/L(20 ºC)

Safety Information

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)

MeSH Entry Terms：

2-ethyl-3-benzofuranyl-4-hydroxy-3,5-diiodophenyl ketone

Benziodarone Use and Manufacturing

A uricosuric drug. It is used to effectively to control hyperuricemia in renal transplantation.

Computed Properties

Molecular Weight:518.08
XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:517.88759
Monoisotopic Mass:517.88759
Topological Polar Surface Area:50.4
Heavy Atom Count:22
Complexity:405
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes