Piroxantrone
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Piroxantrone
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CAS No:
91441-23-5
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Formula:
C21H25N5O4
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Chemical Name:
Piroxantrone
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Synonyms:
Dibenz[cd,g]indazol-6(2H)-one,5-[(3-aminopropyl)amino]-7,10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-;Anthra[1,9-cd]pyrazol-6(2H)-one,5-[(3-aminopropyl)amino]-7,10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-;5-[(3-Aminopropyl)amino]-7,10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]dibenz[cd,g]indazol-6(2H)-one;PD 111815;NCS 349174;Oxantrazole;Piroxantrone;Dup 942;ZINC 01581128
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CAS No:
Description
Piroxantrone is an anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04)
Safety Information
Bulk: Samples stored at 25 °C under both light and dark conditions at 50 °C in the dark for three months showed no significant degradation (HPLC). Solution: A solution containing 10.2 mg/mL in water showed approximately 5% degradation in 24 hours. The test sample exhibited < 10% degradation in 48 hours.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-
Computed Properties
Molecular Weight:411.5
XLogP3:-1.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:411.19065430
Monoisotopic Mass:411.19065430
Topological Polar Surface Area:143
Heavy Atom Count:30
Complexity:997
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- 3-methylbutanal
- ivorit
- cro3
- hexane sds
- dichlorine heptoxide
- isopropyl ether