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Chlorisondamine

Chlorisondamine structure

CAS No:
69-27-2
Formula:
C14H20Cl4N2.2Cl
Chemical Name:
Chlorisondamine
Synonyms:
1H-Isoindolium,4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-,chloride (1:2);4,5,6,7-Tetrachloro-2-(2-dimethylaminoethyl)-2-methylisoindolinium chloride methochloride;Isoindolinium,4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonio)ethyl]-,dichloride;1H-Isoindolium,4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-,dichloride;SU 3088;Chlorisondamine;Chlorisondamine chloride;N-[(2-Dimethylammonium)ethyl]-4,5,6,7-tetrachloroisoindolinium dimethochloride;Ecolid;Ecolid chloride;Hisindamone A;Hisindamon;Chlorisondamin;303-92-4
Categories:
Organic Chemistry > Amides

Description

A nicotinic antagonist used primarily as a ganglionic blocker in animal research. It has been used as an antihypertensive agent but has been supplanted by more specific drugs in most clinical applications.

Chlorisondamine Basic Attributes

Molecular Weight：

611.94300

Exact Mass：

609.84700

UNII：

7B58W7756G

DSSTox ID：

DTXSID7046332

Characteristics

PSA：

Density：

1.4157 (rough estimate)

Melting Point：

261 °C (decomp)

Safety Information

wgk germany：

hazard class code：

22-50

safety instructions：

S60;S61

Marks：

Xn,N

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery. (See all compounds classified as Ganglionic Blockers.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Chloride, Chlorisondamine

Chlorisondamine Use and Manufacturing

Biochemical probe in nicotinic receptor studies.

Computed Properties

Molecular Weight:429.0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:427.972815
Monoisotopic Mass:425.975765
Heavy Atom Count:22
Complexity:336
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes