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Benidipine hydrochloride

Benidipine hydrochloride structure

CAS No:
91599-74-5
Formula:
C28H31N3O6.ClH
Chemical Name:
Benidipine hydrochloride
Synonyms:
3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester,hydrochloride (1:1),(4R)-rel-;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,methyl 1-(phenylmethyl)-3-piperidinyl ester,monohydrochloride,(R*,R*)-(±)-;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester,monohydrochloride,(4R)-rel-;Benidipine hydrochloride;(±)-Benidipine hydrochloride;KW 3049;Coniel;105993-05-3
Categories:
Biochemical Engineering > Inhibitors

Description

Benidipine hydrochloride is a dihydropyridine calcium channel blocker for the treatment of high blood pressure (hypertension).

Benidipine hydrochloride Basic Attributes

Molecular Weight：

505.56

Exact Mass：

541.197964

EC Number：

1592732-453-0

DSSTox ID：

DTXSID2049050

HScode：

2942000000

Characteristics

PSA：

114

XLogP3：

3.74270

Appearance：

yellow

Density：

1.3±0.1 g/cm3

Melting Point：

199.4-200.4 °C

Boiling Point：

645.9ºC at 760 mmHg

Flash Point：

331.9±31.5 °C

Refractive Index：

1.622

Water Solubility：

DMSO: ≥20mg/mL

Storage Conditions：

Desiccate at RT

Toxicity：

Oral-rat LD50: 87.6 mg/kg; Oral-Mouse LD50: 322 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

US7975657

Marks：

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Precautionary statement(s)：

P301 + P310

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

1,4 dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester HCl

Benidipine hydrochloride Use and Manufacturing

A dihydropyridine calcium channel blocker. Antihypertensive.

Computed Properties

Molecular Weight:542.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:541.1979634
Monoisotopic Mass:541.1979634
Topological Polar Surface Area:114
Heavy Atom Count:38
Complexity:933
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a dihydropyridine calcium antagonist, which binds to the DHP binding site of the cell membrane potential-dependent calcium channel, inhibits the influx of calcium ions, and thus dilates the coronary arteries and peripheral blood vessels. It has antihypertensive and anti-angina effects, protects renal function, inhibits vascular remodeling, and protects the vascular endothelium.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Benidipine Hydrochloride Tablets
Ingredients	Benidipine hydrochloride.
Indication	1. Other antihypertensive drugs: The antihypertensive effect is enhanced, which may cause excessive lowering of blood pressure. 2. Digoxin: Inhibits digoxin secretion in the renal tubules, causing an increase in digoxin concentration in the blood. It may cause digitalis poisoning. 3. Cimetidine: Cimetidine inhibits calcium antagonist metabolizing enzymes in liver microsomes, while reducing gastric acid and increasing drug absorption. It may cause excessive lowering of blood pressure. 4. Rifampicin: Rifampicin induces drug metabolizing enzymes in the liver, promotes calcium antagonist metabolism, and can reduce the blood concentration of benidipine, weakening the antihypertensive effect. 5. Grapefruit juice: Grapefruit juice inhibits the metabolism of this product in the liver, causing an increase in the blood concentration of this product. It may cause excessive lowering of blood pressure.
Specifications	8mg*7 tablets/box (film coated)

Benidipine Hydrochloride

Benidipine Hydrochloride Tablets
Ingredients	The active ingredient of this product is benidipine hydrochloride
Indication	1. Other antihypertensive drugs: The antihypertensive effect is enhanced, which may cause excessive lowering of blood pressure. 2. Digoxin: Inhibits digoxin secretion in the renal tubules, causing an increase in digoxin concentration in the blood. It may cause digitalis poisoning. 3. Cimetidine: Cimetidine inhibits calcium antagonist metabolizing enzymes in liver microsomes, while reducing gastric acid and increasing drug absorption. It may cause excessive lowering of blood pressure. 4. Rifampicin: Rifampicin induces drug metabolizing enzymes in the liver, promotes calcium antagonist metabolism, and can reduce the blood concentration of benidipine, weakening the antihypertensive effect. 5. Grapefruit juice: Grapefruit juice inhibits the metabolism of this product in the liver, causing an increase in the blood concentration of this product. It may cause excessive lowering of blood pressure.
Specifications	4mg

See More Related Drugs

Registered Holders

Weijian (China) Pharmaceutical Co., Ltd.

China
Active
ILDONG PHARMACEUTICAL CO., LTD.

South Korea
Active
株式会社パーマケム・アジア

Japan
Active

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