Hyoscyamine sulfate
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Hyoscyamine sulfate
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CAS No:
620-61-1
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Formula:
C17H23NO3.1/2H2O4S
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Chemical Name:
Hyoscyamine sulfate
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Synonyms:
Benzeneacetic acid,α-(hydroxymethyl)-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,(αS)-,sulfate (2:1);1αH,5αH-Tropan-3α-ol,(-)-tropate (ester),sulfate (2:1) (salt);Benzeneacetic acid,α-(hydroxymethyl)-,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,[3(S)-endo]-,sulfate (2:1) (salt);Benzeneacetic acid,α-(hydroxymethyl)-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,(αS)-,sulfate (2:1) (salt);Hyoscyamine sulfate (2:1) (salt);Hyoscyamine sulfate;Levsinex;Levsin sulfate;Egazil;Hyoscyamine sulfate (2:1);Levsin;NuLev;1976-91-6;3715-52-4
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CAS No:
Description
L-Hyoscyamine sulfate (Daturine sulfate) is a tropane alkaloid that is a secondary metabolite found in certain plants of the solanaceae family. In vitro it has been shown to be an antagonist of mAChR[1].
The 3(S)-endo isomer of atropine.
Safety Information
26/28
1-24/25-45
YM6107000
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)|Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (See all compounds classified as Adjuvants, Anesthesia.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)
Anaspaz
Hyoscyamine sulfate Use and Manufacturing
Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)-, sulfate (2:1): INACTIVE
Computed Properties
Molecular Weight:676.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:10
Exact Mass:676.30296691
Monoisotopic Mass:676.30296691
Topological Polar Surface Area:183
Heavy Atom Count:47
Complexity:434
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Belladonna alkaloid, anticholinergic/antimuscarinic; inhibits muscarinic actions of acetylcholine, reduces muscle spasms in digestive or urinary tract, and decreases glandular secretions.
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