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Fosphenytoin sodium

Fosphenytoin sodium structure

CAS No:
92134-98-0
Formula:
C16H15N2O6P.2Na
Chemical Name:
Fosphenytoin sodium
Synonyms:
2,4-Imidazolidinedione,5,5-diphenyl-3-[(phosphonooxy)methyl]-,sodium salt (1:2);2,4-Imidazolidinedione,5,5-diphenyl-3-[(phosphonooxy)methyl]-,disodium salt;ACC 9653;Fosphenytoin sodium;ACC 9653-010;CI 982;Pro-Epanutin;Cetebyx;Fostoin;Disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate;1159882-32-2
Categories:
Analytical Chemistry > Standard

Description

Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.

Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex. This leads to a suppression of excessive neuronal firing and spread of seizure activity. Other physiologic effects from actions of phenytoin include modulation of the voltage-dependent calcium channels of neurons, inhibition of calcium flux across neuronal membranes and enhancement of sodium-potassium ATPase activity of neurons and glial cells. (NCI05)

Fosphenytoin sodium Basic Attributes

Molecular Weight：

406.24

Exact Mass：

406.03100

EC Number：

618-823-4

UNII：

7VLR55452Z

DSSTox ID：

DTXSID1044271

NCI Thesaurus Code：

C47543

HScode：

2933790090

Characteristics

PSA：

122

XLogP3：

2.69190

Appearance：

white to tan

Melting Point：

220° (softens)

Water Solubility：

H2O: ≥15mg/mL

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice, rats (mg/kg): 234, 363 i.v. (Smith)

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

45-61-22

safety instructions：

53-36/37-45

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. (See all compounds classified as Sodium Channel Blockers.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

MeSH Entry Terms：

3-(hydroxymethyl)phenytoin disodium phosphate

Fosphenytoin sodium Use and Manufacturing

Uses

Anti epileptic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:406.24
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:406.03066170
Monoisotopic Mass:406.03066170
Topological Polar Surface Area:122
Heavy Atom Count:27
Complexity:536
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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Pharma Grade Fosphenytoin Sodium CAS 92134-98-0 98% white crystalline powder

CAS No.: 92134-98-0

Grade: Pharmaceutical Grade

Content: 98%

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